Evidence map›Paper›PMID 27915383›Full record

ArticlePurinergic signalling2017

A covalent antagonist for the human adenosine A

Xue Yang, Guo Dong, Thomas J M Michiels, Eelke B Lenselink, Laura Heitman, Julien Louvel, Ad P IJzerman

Open access · hybridAbstract read
In one paragraph

Article in Purinergic signalling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Irreversible Antagonists for the Adenosine AMolecules (Basel, Switzerland) · 2022
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Covalent Inhibition of the Histamine HMolecules (Basel, Switzerland) · 2019
    Article
  12. Chemical Probes for the Adenosine Receptors.Pharmaceuticals (Basel, Switzerland) · 2019
    Review
  13. Article
  14. Article
  15. Article
  16. An Affinity-Based Probe for the Human Adenosine AJournal of medicinal chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Xue YangDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands.
Guo DongJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, 221004, China.
Thomas J M MichielsDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands.
Eelke B LenselinkDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands.
Laura HeitmanDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands.
Julien LouvelDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands.
Ad P IJzermanDivision of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands. ijzerman@lacdr.leidenuniv.nl.
Centre for Human Drug Research · NLLeiden University · NLXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The structure of the human A

Indexed as

Adenosine A2 Receptor AntagonistsHumansReceptor, Adenosine A2ATriazinesTriazolesAdenosine A2 Receptor AntagonistsLUF7445Receptor, Adenosine A2ATriazinesTriazolesA2A adenosine receptorAdenosineCovalent antagonistG protein-coupled receptorsRadioligand binding

Identifiers

PMID27915383
PMCPMC5432479
OpenAlexW2558502190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.