Evidence map›Paper›PMID 27915024›Full record

ReviewActa biomaterialia2017

Extracellular matrix hydrogels from decellularized tissues: Structure and function.

Lindsey T Saldin, Madeline C Cramer, Sachin S Velankar, Lisa J White, Stephen F Badylak

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta biomaterialia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 348 papers.

0numbers the graph read from it
0cells of the map it votes in
348citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

348 citing papers in PubMed.

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288 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lindsey T SaldinDepartment of Bioengineering, University of Pittsburgh, 360B CNBIO, 300 Technology Drive, Pittsburgh, PA 15219, USA; McGowan Institute for Regenerative Medicine, Suite 300, 450 Technology Drive, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: saldinlt@upmc.edu.
Madeline C CramerDepartment of Bioengineering, University of Pittsburgh, 360B CNBIO, 300 Technology Drive, Pittsburgh, PA 15219, USA; McGowan Institute for Regenerative Medicine, Suite 300, 450 Technology Drive, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: cramerm2@upmc.edu.
Sachin S VelankarDepartment of Chemical Engineering, University of Pittsburgh, 940 Benedum Hall, Pittsburgh, PA 15261, USA. Electronic address: velankar@pitt.edu.
Lisa J WhiteMcGowan Institute for Regenerative Medicine, Suite 300, 450 Technology Drive, University of Pittsburgh, Pittsburgh, PA 15219, USA; School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Electronic address: lisa.white@nottingham.ac.uk.
Stephen F BadylakDepartment of Bioengineering, University of Pittsburgh, 360B CNBIO, 300 Technology Drive, Pittsburgh, PA 15219, USA; McGowan Institute for Regenerative Medicine, Suite 300, 450 Technology Drive, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address: badylaks@upmc.edu.

Funding

Cellular Approaches to Tissue Engineering/RegenerationT32EB001026 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN, ANDREW W, MONGA, SATDARSHAN SINGH · 2003 to 2024
$5.5M
Understanding Esophageal Adenocarcinoma Progression Using Inflammatory and Neoplastic Extracellular Matrix HydrogelsF31CA210694 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SALDIN, LINDSEY T. · 2016 to 2017
$80k
NCI NIH HHS F31 CA210694NIBIB NIH HHS T32 EB001026
6 · The paper itself

Abstract

Extracellular matrix (ECM) bioscaffolds prepared from decellularized tissues have been used to facilitate constructive and functional tissue remodeling in a variety of clinical applications. The discovery that these ECM materials could be solubilized and subsequently manipulated to form hydrogels expanded their potential in vitro and in vivo utility; i.e. as culture substrates comparable to collagen or Matrigel, and as injectable materials that fill irregularly-shaped defects. The mechanisms by which ECM hydrogels direct cell behavior and influence remodeling outcomes are only partially understood, but likely include structural and biological signals retained from the native source tissue. The present review describes the utility, formation, and physical and biological characterization of ECM hydrogels. Two examples of clinical application are presented to demonstrate in vivo utility of ECM hydrogels in different organ systems. Finally, new research directions and clinical translation of ECM hydrogels are discussed. STATEMENT OF SIGNIFICANCE: More than 70 papers have been published on extracellular matrix (ECM) hydrogels created from source tissue in almost every organ system. The present manuscript represents a review of ECM hydrogels and attempts to identify structure-function relationships that influence the tissue remodeling outcomes and gaps in the understanding thereof. There is a Phase 1 clinical trial now in progress for an ECM hydrogel.

Indexed as

AnimalsExtracellular MatrixHumansHydrogelsMaterials TestingTissue EngineeringHydrogelsBiomaterialDecellularizationExtracellular matrixHydrogelInjectableNaturally derivedRegenerative medicineTissue engineering

Identifiers

PMID27915024
PMCPMC5253110

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.