Evidence map›Paper›PMID 27914987›Full record

ArticleToxicology letters2017

Tetrabromobisphenol A activates the hepatic interferon pathway in rats.

J K Dunnick, D L Morgan, S A Elmore, K Gerrish, A Pandiri, T V Ton, K R Shockley, B A Merrick

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

J K DunnickToxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: dunnickj@niehs.nih.gov.
D L MorganNTP Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
S A ElmoreCellular and Molecular Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
K GerrishMolecular Genomics Core, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
A PandiriCellular and Molecular Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
T V TonCellular and Molecular Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
K R ShockleyBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
B A MerrickBiomolecular Screening Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
National Institute of Environmental Health Sciences · US

Funding

Toxicological Assessments for the National Toxicology ProgramZIAES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2016 to 2019
$31.9M
Gene Expression and MicroarraysZICES102445 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GERRISH, KEVIN · 2009 to 2025
$31.6M
Intramural NIH HHS Z99 ES999999
6 · The paper itself

Abstract

Tetrabromobisphenol A (TBBPA) is a widely used flame retardant in printed circuit boards, paper, and textiles. In a two-year study, TBBPA showed evidence of uterine tumors in female Wistar-Han rats and liver and colon tumors in B6C3F1 mice. In order to gain further insight into early gene and pathway changes leading to cancer, we exposed female Wistar Han rats to TBBPA at 0, 25, 250, or 1000mg/kg (oral gavage in corn oil, 5×/week) for 13 weeks. Because at the end of the TBBPA exposure period, there were no treatment-related effects on body weights, liver or uterus lesions, and liver and uterine organ weights were within 10% of controls, only the high dose animals were analyzed. Analysis of the hepatic and uterine transcriptomes showed TBBPA-induced changes primarily in the liver (1000mg/kg), with 159 transcripts corresponding to 132 genes differentially expressed compared to controls (FDR=0.05). Pathway analysis showed activation of interferon (IFN) and metabolic networks. TBBPA induced few molecular changes in the uterus. Activation of the interferon pathway in the liver occurred after 13-weeks of TBBPA exposure, and with longer term TBBPA exposure this may lead to immunomodulatory changes that contribute to carcinogenic processes.

Indexed as

AnimalsDose-Response Relationship, DrugFemaleFlame RetardantsGene Expression RegulationInterferonsLiverMolecular StructurePolybrominated BiphenylsRatsUterusFlame RetardantsInterferonsPolybrominated Biphenylstetrabromobisphenol AInterferon response transcriptsMicroarrayPathway analysisTetrabromobisphenol AToxicogenomics

Identifiers

PMID27914987
PMCPMC5791538
OpenAlexW2558661329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.