Trial reportAmerican journal of ophthalmology2017
Estimating Optical Coherence Tomography Structural Measurement Floors to Improve Detection of Progression in Advanced Glaucoma.
Trial report in American journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00221897 (Diagnostic Innovations in Glaucoma Study), which is not on this map. Cited by 116 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnostic Innovations in Glaucoma Study
Who cites it
116 citing papers in PubMed.
- Artificial Intelligence in Glaucoma Detection and Progression.Advances in ophthalmology and optometry · 2026Article
- Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures.Investigative ophthalmology & visual science · 2026Article
- Comparative analysis of optical coherence tomography angiography metrics in primary open-angle glaucoma and ocular hypertension.BMC ophthalmology · 2026Article
- Long-Term Clinical Course and Progression Patterns of Normal-Tension Glaucoma Following Disc Hemorrhage.Investigative ophthalmology & visual science · 2026Article
- Nonaxonal content of the circumpapillary retinal nerve fiber layer in experimental glaucoma.Optometry and vision science : official publication of the American Academy of Optometry · 2026Article
- Two-year OCT follow-up in multiple sclerosis patients on Ofatumumab shows retinal preservation over non-antiCD20 treatments.Journal of neurology · 2026Observational
- Comparing the Utility of Retinal Nerve Fiber Layer and Ganglion Cell Inner Plexiform Layer OCT Changes to Detect Glaucoma Progression.Ophthalmology · 2026Article
- Early Diagnosis of Glaucoma By Optical Coherence Tomography: A Systematic Review and Network Meta-analysis.Journal of ophthalmic & vision research · 2026Article
- Structure function relationships differ between optic neuritis and glaucoma with comparable optical coherence tomography findings.PloS one · 2026Article
- [Progression assessment of glaucoma].Die Ophthalmologie · 2025Review
- Percentage macular ganglion cell complex and peripapillary retinal nerve fiber layer loss in different stages of glaucoma.Indian journal of ophthalmology · 2025Article
- Baseline choroidal microvasculature dropout as a predictor of rapid global structural loss in open-angle glaucoma.Scientific reports · 2025Article
- Detecting glaucoma worsening using optical coherence tomography derived visual field estimates.Scientific reports · 2025Article
- Comparing structural and vascular parameters between advanced pseudoexfoliation glaucoma and primary open angle glaucoma using optical coherence tomography angiography.BMC ophthalmology · 2025Article
- Impact of race and ethnicity on glaucoma progression detection by perimetry and optical coherence tomography.Scientific reports · 2024Article
- Ophthalmic Findings in the KIF1A-Associated Neurologic Disorder (KAND).American journal of ophthalmology · 2024Article
- Impact of Race and Ethnicity on Glaucoma Progression Detection by Perimetry and Optical Coherence Tomography.Research square · 2024Article
- Rapid Campimetry in glaucoma - correspondence with standard perimetry and OCT.Scientific reports · 2024Article
- A Novel Approach To Predict Glaucomatous Impairment in the Central 10° Visual Field, Excluding the Effect of Cataract.Translational vision science & technology · 2024Article
- The thickness of the retinal nerve fiber layer, macula, and ganglion cell-inner plexiform layer in people with drug-resistant epilepsy.Epilepsia open · 2024Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purpose"Floor effects" in retinal imaging are defined as the points at which no further structural loss can be detected. We estimated the measurement floors for spectral-domain optical coherence tomography (SDOCT) measurements and compared global change over time in advanced glaucoma eyes.
designValidity study to investigate measurement floors.
methodsA longitudinal "Variability group" of 41 eyes with moderate to advanced glaucoma (standard automated perimetry mean deviation ≤-8 dB) was used to estimate measurement floors. Minimum rim width (MRW), ganglion cell-inner plexiform layer thickness (GC-IPLT), and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) were determined. Floors were defined as the average image area with a loss less than first-percentile confidence interval of the variability in this group. Global rate of change and percentage of the region of interest that did not reach the measurement floor at baseline were calculated in 87 eyes with advanced glaucoma (SAP MD ≤-12 dB).
resultsGlobal change over time in longitudinal eyes was -1.51 μm/year for MRW, -0.21 μm/year for GC-IPL, and -0.36 μm/year cpRNFL (all P ≤ .03). The percentage of region of interest that did not reach the floor at baseline was 19% for MRW, 36% for GC-IPLT, and 14% for cpRNFLT. Average (± standard deviation) floors were 105 μm (± 15.9 μm) for MRW, 38 μm (± 3.4 μm) for GC-IPLT, and 38 μm (± 4.2 μm) for cpRNFLT.
conclusionsIn advanced glaucoma, more GC-IPL tissue remains above the measurement floor compared with other measurements, suggesting GC-IPL thickness is the better candidate for detecting progression. Progression in SDOCT measurements is observable in advanced disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.