Evidence map›Paper›PMID 27914377›Full record

ArticleThe Journal of the Acoustical Society of America2016

Evaluating multipulse integration as a neural-health correlate in human cochlear-implant users: Relationship to spatial selectivity.

Ning Zhou, Bryan E Pfingst

Abstract read
In one paragraph

Article in The Journal of the Acoustical Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Assessing the Relationship Between Pitch Perception and Neural Health in Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2022
    Article
  2. Cochlear Implant Research and Development in the Twenty-first Century: A Critical Update.Journal of the Association for Research in Otolaryngology : JARO · 2021
    Review
  3. Article
  4. Article
  5. Article
  6. Effects of Electrode Location on Estimates of Neural Health in Humans with Cochlear Implants.Journal of the Association for Research in Otolaryngology : JARO · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Psychophysical Tuning Curves as a Correlate of Electrode Position in Cochlear Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2018
    Article
  11. Article
  12. Temporal Modulation Detection Depends on Sharpness of Spatial Tuning.Journal of the Association for Research in Otolaryngology : JARO · 2018
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ning ZhouDepartment of Communication Sciences and Disorders, East Carolina University, Greenville, North Carolina 27834, USA.
Bryan E PfingstDepartment of Otolaryngology, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109-5616, USA.

Funding

Scientific Synergy CoreP30DC005188 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALTSCHULER, RICHARD A · 2002 to 2016
$10.3M
Across-Site Patterns of Perception with Cochlear ImplantsR01DC010786 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PFINGST, BRYAN E · 2010 to 2014
$1.6M
Assessing non-invasive measures of neural health in cochlear implant users and the clinical implicationsR03DC014771 · NIDCD · EAST CAROLINA UNIVERSITY · PI ZHOU, NING · 2016 to 2018
$432k
NIDCD NIH HHS P30 DC005188NIDCD NIH HHS R01 DC010786NIDCD NIH HHS R03 DC014771
6 · The paper itself

Abstract

The decrease of psychophysical detection thresholds as a function of pulse rate for a fixed-duration electrical pulse train is referred to as multipulse integration (MPI). The MPI slopes correlate with anatomical and physiological indices of cochlear health in guinea pigs with cochlear implants. The aim of the current study was to assess whether the MPI slopes were related to the spatial spread of activation by electrical stimulation. The hypothesis was that MPI is dependent on the total number of excitable neurons at the stimulation site, with broader neural excitation producing a steeper threshold decrease as a function of stimulation rate. MPI functions were measured at all stimulation sites in 22-site electrode arrays in human subjects. Some sites with steep MPI functions and other sites with shallow functions were assessed for spatial spread of excitation at 900 pps using a forward-masking paradigm. The results showed a correlation between the slopes of the forward-masking functions and the steepness of MPI, with broader stimulation predicting greater integration. The results are consistent with the idea that integration of multiple pulses in a pulse train relies on the number of excitable neurons at the stimulation site.

Indexed as

Cochlear ImplantsAnimalsAuditory ThresholdCochleaCochlear ImplantationElectric StimulationGuinea PigsHumans

Identifiers

PMID27914377
PMCPMC5392072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.