ArticleBiomaterials2017
Automated quantification of three-dimensional organization of fiber-like structures in biological tissues.
Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Integrating serial block-face SEM with voxel-based finite element analysis for high-fidelity micromechanical modelling of anisotropic soft tissues: application to human dermis.Biomechanics and modeling in mechanobiology · 2026Article
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- Assessing preterm risk via label-free, multiparametric imaging of collagen fiber remodeling in the cervix.Biomedical optics express · 2026Article
- Decoding elastin-collagen resemblance in keloid scar through label-free imaging and machine learning.Journal of biomedical optics · 2026Article
- Intraoperative biopsy imaging of lung cancer risk.Communications medicine · 2026Article
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- Assessment of Collagen and Fibroblast Properties via Label-Free Higher Harmonic Generation Microscopy in Three-Dimensional Models of Osteogenesis Imperfecta and Ehlers-Danlos Syndrome.International journal of molecular sciences · 2025Article
- Keratoconus diagnosis based on macro-micro corneal characteristics via optical coherence tomography.Biomedical optics express · 2025Article
- Fatigue loading and volumetric microscopy demonstrate changes to the mouse cervix throughout and after pregnancy.Connective tissue research · 2025Article
- An algorithmic and software framework to incorporate orientation distribution functions in finite element simulations for biomechanics and biophysics.Acta biomaterialia · 2025Article
- Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy.Nature communications · 2025Article
- Architecture-driven quantitative nanoscopy maps cytoskeleton remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Quantification of age-related changes in the structure and mechanical function of skin with multiscale imaging.GeroScience · 2024Article
- Quantitative Assessment of Collagen Remodeling during a Murine Pregnancy.ACS photonics · 2024Article
- Mechanical Models of Collagen Networks for Understanding Changes in the Failure Properties of Aging Skin.Journal of biomechanical engineering · 2024Article
- Fourier transform-based method for quantifying the three-dimensional orientation distribution of fibrous units.Scientific reports · 2024Article
- Extracellular Hsp90 Binds to and Aligns Collagen-1 to Enhance Breast Cancer Cell Invasiveness.Cancers · 2023Article
- Evaluation of a polarization-enhanced laparoscopy prototype for improved intra-operative visualization of peritoneal metastases.Scientific reports · 2023Article
- Label-free, multi-parametric assessments of cell metabolism and matrix remodeling within human and early-stage murine osteoarthritic articular cartilage.Communications biology · 2023Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Fiber-like structures are prevalent in biological tissues, yet quantitative approaches to assess their three-dimensional (3D) organization are lacking. We develop 3D directional variance, as a quantitative biomarker of truly 3D fibrillar organization by extending the directional statistics formalism developed for describing circular data distributions (i.e. when 0° and 360° are equivalent) to axial ones (i.e. when 0° and 180° are equivalent). Significant advantages of this analysis include its time efficiency, sensitivity and ability to provide quantitative readouts of organization over different size scales of a given data set. We establish a broad range of applications for this method by characterizing collagen fibers, neuronal axons and fibroblasts in the context of cancer diagnostics, traumatic brain injury and cell-matrix interactions in developing engineered tissues. This method opens possibilities for unraveling in a sensitive, and quantitative manner the organization of essential fiber-like structures in tissues and ultimately its impact on tissue function.
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Registered trials
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