ArticleBiomaterials2017
Pattern-based sensing of triple negative breast cancer cells with dual-ligand cofunctionalized gold nanoclusters.
Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A fingerprint-based polymeric sensing platform for comprehensive quality assessment of complex culture media in cell manufacturing.Chemical science · 2026Article
- BioGoldNCDB: A Database of Gold Nanoclusters and Related Nanoparticles with Biomedical Activity.Molecules (Basel, Switzerland) · 2025Review
- Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays.BBA advances · 2025Article
- Red blood cell-derived materials for cancer therapy: Construction, distribution, and applications.Materials today. Bio · 2024Review
- Chemical tongues as multipurpose bioanalytical tools for the characterization of complex biological samples.Biophysics and physicobiology · 2024Review
- Engineered Biosensors for Diagnosing Multidrug Resistance in Microbial and Malignant Cells.Biosensors · 2023Review
- Mesoporous silica-loaded gold nanocluster with enhanced fluorescence and ratiometric fluorescent detection of thiram in foods.Mikrochimica acta · 2021Article
- Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells.Biosensors · 2021Review
- Biomolecular interactions of ultrasmall metallic nanoparticles and nanoclusters.Nanoscale advances · 2021Review
- Triple Negative Breast Cancer: A Review of Present and Future Diagnostic Modalities.Medicina (Kaunas, Lithuania) · 2021Review
- Pattern-recognition-based Sensor Arrays for Cell Characterization: From Materials and Data Analyses to Biomedical Applications.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Review
- High-content and high-throughput identification of macrophage polarization phenotypes.Chemical science · 2020Article
- A fluorescence signal amplification strategy for modification-free ratiometric determination of tyrosinase in situ based on the use of dual-templated copper nanoclusters.Mikrochimica acta · 2020Article
- Array-based "Chemical Nose" Sensing in Diagnostics and Drug Discovery.Angewandte Chemie (International ed. in English) · 2019Review
- Cyclodextrin-Promoted Fluorescence Detection of Aromatic Toxicants and Toxicant Metabolites in Commercial Milk Products.Food analytical methods · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Early detection of breast cancer is a critical component in patient prognosis and establishing effective therapy regimens. Here, we developed an easily accessible yet potentially powerful sensor to detect cancer cell targets by utilizing seven dual-ligand cofunctionalized gold nanoclusters (AuNCs) as both effective cell recognition elements and signal transducers. On the basis of this AuNC multichannel sensor, we have successfully distinguished healthy, cancerous and metastatic human breast cells with excellent reproducibility and high sensitivity. Triple negative breast cancer cells (TNBCs), which exhibit low expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2, were identified. The high accuracy of the blind breast cell sample tests further validates the practical application of the sensor array. In addition, the versatility of the sensor array is further justified by identifying amongst distinct cell types, different cell concentrations and cell mixtures. Notably, the drug-resistant cancer cells can also be efficiently discriminated. Furthermore, the dual-ligand cofunctionalized AuNCs can efficiently differentiate different cells from the peripheral blood of tumor-free and tumor-bearing mice. Taken together, this fluorescent AuNCs based array provides a powerful cell analysis tool with potential applications in biomedical diagnostics.
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