Evidence map›Paper›PMID 27914198›Full record

ArticleeLife2016

Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3.

Jarrett Smith, Deepika Calidas, Helen Schmidt, Tu Lu, Dominique Rasoloson, Geraldine Seydoux

Abstract read
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed.

  1. Reversible Nucleolar Complex Coacervation by Short Cationic Peptides.Journal of the American Chemical Society · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. How germ granules promote germ cell fate.Nature reviews. Genetics · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. [Latest Findings on Phase Separation of Cytomechanical Proteins].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Article
  18. Review
  19. Review
  20. Article

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jarrett SmithDepartment of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0001-6354-6551
Deepika CalidasDepartment of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0002-0859-5390
Helen SchmidtDepartment of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0002-3449-2790
Tu LuDepartment of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0002-5697-300X
Dominique RasolosonDepartment of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States.
Geraldine SeydouxDepartment of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0001-8257-0493

Funding

Predoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6M
REGULATION OF GERM CELL FATE DURING EMBRYOGENESISR01HD037047 · NICHD · JOHNS HOPKINS UNIVERSITY · PI GERALDINE Catherine Joelle SEYDOUX · 1999 to 2026
$4.3M
Regulation of Germ Cell Fate During EmbryogenesisR37HD037047 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SEYDOUX, GERALDINE CATHERINE JOELLE · 2016 to 2025
$3.8M
Howard Hughes Medical InstituteNICHD NIH HHS R01 HD037047NICHD NIH HHS R37 HD037047NIGMS NIH HHS T32 GM007814
6 · The paper itself

Abstract

RNA granules are non-membrane bound cellular compartments that contain RNA and RNA binding proteins. The molecular mechanisms that regulate the spatial distribution of RNA granules in cells are poorly understood. During polarization of the

Indexed as

Caenorhabditis elegans ProteinsIntrinsically Disordered ProteinsProtein BindingRNARNA-Binding ProteinsCaenorhabditis elegans ProteinsIntrinsically Disordered ProteinsMEG-3 protein, C elegansMEX-5 protein, C elegansRNARNA-Binding ProteinsC. eleganscell biologydevelopmental biologygermlineMEG-3MEX-5P granulesphase separationRNA granulesstem cells

Identifiers

PMID27914198
PMCPMC5262379

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.