Evidence map›Paper›PMID 27913968›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2017

Post-ganglionic autonomic neuropathy associated with anti-glutamic acid decarboxylase antibodies.

E Fileccia, R Rinaldi, R Liguori, A Incensi, R D'Angelo, M P Giannoccaro, V Donadio

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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Neurological Syndromes Associated with Anti-GAD Antibodies.International journal of molecular sciences · 2020
    Review
  4. Observational
  5. Cerebellar disease associated with anti-glutamic acid decarboxylase antibodies: review.Journal of neural transmission (Vienna, Austria : 1996) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

E FilecciaDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. enricofileccia@gmail.com.ORCID 0000-0002-3943-7539
R RinaldiNeurology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy.
R LiguoriDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
A IncensiIRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.
R D'AngeloNeurology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy.
M P GiannoccaroDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
V DonadioIRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.
Institute of Neurological Sciences · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAntibodies to glutamic acid decarboxylase (GAD-Abs) have been associated with several conditions, rarely involving the autonomic nervous system. Here, we describe two patients complaining of autonomic symptoms in whom a post-ganglionic autonomic neuropathy has been demonstrated in association with significantly elevated serum and CSF GAD-Abs levels.

methodsPatients underwent nerve conduction studies, sympathetic skin response testing, evaluation of autonomic control of the cardiovascular system and skin biopsy. Also, serum screening to exclude predisposing causes of peripheral neuropathy was performed. Anti-GAD65 antibodies were evaluated in serum and CSF.

resultsGAD-Abs titer was increased in both serum and CSF in both patients. Sympathetic skin response was absent and skin biopsy revealed a non-length-dependent small-fiber neuropathy with sympathetic cholinergic and adrenergic post-ganglionic damage in both patients. Nerve conduction studies and evaluation of autonomic control of the cardiovascular system were normal in both patients. Both patients were treated with steroids with good, but partial, (patient 2) recovery of the autonomic dysfunctions.

conclusionsAlthough the pathophysiological mechanisms involved are not fully defined, GAD-abs positivity in serum and CSF should be searched in patients with autonomic neuropathy when no other acquired causes are evident. This positivity may help to clarify autoimmune etiology and, subsequently, to consider immunomodulatory treatment.

Indexed as

AutoantibodiesAutonomic Fibers, PostganglionicAutonomic Nervous System DiseasesGlutamate DecarboxylaseHumansMaleMiddle AgedNeural ConductionAutoantibodiesGlutamate DecarboxylaseAnti-GAD antibodiesAnti-glutamic acid decarboxylase antibodiesAutonomic neuropathyPost-ganglionic autonomic neuropathySkin biopsy

Identifiers

PMID27913968
OpenAlexW2559600260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.