Evidence map›Paper›PMID 27913855›Full record

ReviewUrolithiasis2017

What can the microstructure of stones tell us?

James C Williams, Elaine Worcester, James E Lingeman

Abstract readReview
In one paragraph

Review in Urolithiasis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

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  10. SEM-EDX linear scanning: a new tool for morpho-compositional analysis of growth bands in urinary stones.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

James C WilliamsDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive MS 5065A, Indianapolis, IN, 46202-5120, USA. jwillia3@iupui.edu.
Elaine WorcesterNephrology Section, University of Chicago, Chicago, IL, USA.
James E LingemanDepartment of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USUniversity of Chicago · US

Funding

SWL AND RENAL INJURY AND STONE COMMINUTIONP01DK043881 · NIDDK · UNIVERSITY OF WASHINGTON · PI WILLIAMS, JAMES C · 1994 to 2023
$33.5M
STONE FORMATION IN GENETIC HYPERCALCIURIAP01DK056788 · NIDDK · UNIVERSITY OF CHICAGO · PI WILLIAMS, JAMES C · 2000 to 2021
$22.5M
SkyScan 1172 High-resolution desk-top micro-CT systemS10RR023710 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI WILLIAMS, JAMES C · 2007 to 2007
$297k
NCRR NIH HHS S10 RR023710NIDDK NIH HHS P01 DK043881NIDDK NIH HHS P01 DK056788
6 · The paper itself

Abstract

How stones are retained within the kidney while small in size is still not fully understood. In this paper, we show two examples of how stones are retained during early growth: one is growth on Randall's (interstitial) plaque, and the other is growth on mineral that has formed as a luminal plug in a terminal collecting duct. These two mechanisms of stone retention during early growth have distinctive morphologic features that can be seen by methods that show the microscopic structure of the stones. Stones growing on Randall's plaque display an apatite region that is typically not large in size (<0.5 mm across) but which usually shows luminal spaces, which are signs of its origin in the connective tissue of the papilla. Stones growing on ductal plugs also show attachment to a piece of apatite, but the apatite regions are typically larger (often >1 mm long and >0.5 mm wide), and they are solid, without spaces running through them. We propose that knowing the mechanisms of stone retention during early stone formation could allow for better treatment of stone diseases.

Indexed as

ApatitesCrystallizationHumansKidney CalculiApatitesImagingNephrolithiasis

Identifiers

PMID27913855
PMCPMC5253090
OpenAlexW2557655763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.