ArticlePerfusion2017
Myocardial cytochrome oxidase activity increases with age and hypoxemia in patients with congenital heart disease.
Article in Perfusion, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Children with single ventricle heart disease have a greater increase in sRAGE after cardiopulmonary bypass.Perfusion · 2024Observational
- Peripheral Blood Mononuclear Cells Mitochondrial Respiration and Superoxide Anion after Heart Transplantation.Journal of clinical medicine · 2022Article
- Molecular Genetics of Lidocaine-Containing Cardioplegia in the Human Heart During Cardiac Surgery.The Annals of thoracic surgery · 2018Article
- Preoperative detrimental effect on cerebral function of severe congenital heart disease.Journal of thoracic disease · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMyocardial tolerance to ischemia is influenced by age and preoperative cyanosis through unknown mechanisms and significantly affects postoperative outcomes. Cytochrome c oxidase (CcOx), the terminal enzyme of the mitochondrial electron transport chain, may play a role in the susceptibility to ischemic-reperfusion (IR) injury. Our study aimed at investigating changes in human myocardial CcOx activity based on age and preoperative oxygen saturation to understand its role in transition from neonatal to mature myocardium and hypoxic conditions.
methodsThe right atrial appendage from patients undergoing first time surgical repair/palliation of congenital heart defects was analyzed for steady state CcOx activity by oxidation of ferrocytochrome c via spectrophotometry and steady state CcOx subunit I protein content by protein immunoblotting. Student's t-test compared CcOx activity and protein levels between patients with preoperative hypoxia and normoxia. Multiple linear regression analysis was used to assess the effects of age and preoperative arterial oxygen saturations (SaO
resultsThirty-two patients with a median (interquartile range) age of 83 days (8-174) and preoperative oxygen saturation 98% (85-100%) were enrolled. Independent of age, preoperative SaO
conclusionsIn patients with congenital heart disease, an increase in CcOx steady state activity is seen with increasing age. Hypoxia leads to upregulation of CcOx steady state activity without an increase in the amount of enzyme protein itself. Higher CcOx activity in older and cyanotic patients may indicate CcOx-dependent reactive oxygen species as the mechanism for IR injury.
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