Evidence map›Paper›PMID 27913761›Full record

ReviewTherapeutic advances in respiratory disease2017

Best practices in the treatment of early cystic fibrosis lung disease.

Marijke Proesmans

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Therapeutic advances in respiratory disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05599958 (Clinical and Genetic Profile of Pediatric Patients With Cystic Fibrosis in Sohag.), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05599958 completednot on this mapstarted 2022, after this paper: background citation

Clinical and Genetic Profile of Pediatric Patients With Cystic Fibrosis in Sohag.

TypeobservationalSponsorSohag UniversityRan2022 to 2023Enrolled152ConditionsCystic FibrosisArmssweat chloride test, genetic testing
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Systemic in utero gene editing as a treatment for cystic fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Review
  5. Observational
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Marijke ProesmansDepartment of Paediatrics, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium.
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For many years, management of cystic fibrosis (CF) lung disease was focused on symptomatic treatment of chronic lung infection, which is characterized by cough and sputum production, leading to progressive lung damage. With increasing survival and better knowledge of the pathogenesis of CF lung disease, it has become clear that treatment has to start very early because lung damage occurs in young patients, often before obvious symptoms appear. The arrival of new cystic fibrosis transmembrane conductance-regulator (CFTR)-correcting therapies will bring more opportunities to prevent the disease, apart from only treating chronic lung infection. In this review, a summary of the current knowledge of early CF lung disease is provided, based on animal model studies, as well as on data obtained from well structured follow-up programs after newborn screening (NBS). The most important clinical guidelines for treating young CF patients are also summarized.

Indexed as

Practice Guidelines as TopicAnimalsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDisease Models, AnimalHumansInfant, NewbornLung DiseasesNeonatal ScreeningCystic Fibrosis Transmembrane Conductance Regulatoranimal modelscystic fibrosisearly therapylung diseasenewborn screening

Identifiers

PMID27913761
PMCPMC5933638
OpenAlexW2559322235

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.