ArticleG3 (Bethesda, Md.)2017
Screening and Analysis of Janelia FlyLight Project Enhancer-Gal4 Strains Identifies Multiple Gene Enhancers Active During Hematopoiesis in Normal and Wasp-Challenged
Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Draper-mediated efferocytosis bybioRxiv : the preprint server for biology · 2026Article
- EnhancerMatcher: comparing cell-type-specific enhancer activity of DNA sequences using deep convolutional neural networks and explainable AI.NAR genomics and bioinformatics · 2025Article
- Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.PLoS genetics · 2024Article
- Host JAK-STAT activity is a target of parasitoid wasp virulence strategies.PLoS pathogens · 2024Article
- Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.bioRxiv : the preprint server for biology · 2023Article
- Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation.Cell metabolism · 2023Article
- A novel role for trithorax in the gene regulatory network for a rapidly evolving fruit fly pigmentation trait.PLoS genetics · 2023Article
- Article
- Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland.PLoS genetics · 2021Article
- Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways ineLife · 2021Article
- Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors ineLife · 2020Article
- A single-cell survey ofeLife · 2020Article
- CCAP regulates feeding behavior via the NPF pathway inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO.Life science alliance · 2020Article
- Review
- The mir-7 and bag of marbles genes regulate Hedgehog pathway signaling in blood cell progenitors in Drosophila larval lymph glands.Genesis (New York, N.Y. : 2000) · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
A GFP expression screen has been conducted on >1000 Janelia FlyLight Project enhancer-Gal4 lines to identify transcriptional enhancers active in the larval hematopoietic system. A total of 190 enhancers associated with 87 distinct genes showed activity in cells of the third instar larval lymph gland and hemolymph. That is, gene enhancers were active in cells of the lymph gland posterior signaling center (PSC), medullary zone (MZ), and/or cortical zone (CZ), while certain of the transcriptional control regions were active in circulating hemocytes. Phenotypic analyses were undertaken on 81 of these hematopoietic-expressed genes, with nine genes characterized in detail as to gain- and loss-of-function phenotypes in larval hematopoietic tissues and blood cells. These studies demonstrated the functional requirement of the
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