Trial reportBMJ open2016
Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study).
Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02123641 (Physical Activity as Intervention Against Age-related Loss of Muscle Mass and Function), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical Activity as Intervention Against Age-related Loss of Muscle Mass and Function
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Study protocol for FAXAge: a randomized, controlled clinical trial of fasting and exercise to slow aging in humans.GeroScience · 2026Trial
- Trial
- No long-term benefits from resistance training on brain grey matter volumes in active older adults at retirement age.BMC geriatrics · 2025Trial
- Enhancement of Lower Limb Muscle Strength and Reduction of Inflammation in the Elderly: A Randomized, Double-Blind Clinical Trial ComparingNutrients · 2025Trial
- Is it all in the baseline? Trajectories of chair stand performance over 4 years and their association with grey matter structure in older adults.Human brain mapping · 2023Trial
- Right-left asymmetry in corticospinal tract microstructure and dexterity are uncoupled in late adulthood.NeuroImage · 2021Trial
- Load magnitude affects patellar tendon mechanical properties but not collagen or collagen cross-linking after long-term strength training in older adults.BMC geriatrics · 2019Trial
- Rising burden of fall-induced hip fractures in China: accelerating male-specific trends and persistent gender disparities from Global Burden of Disease 2021.Acta orthopaedica et traumatologica turcica · 2026Article
- No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts.Scientific reports · 2025Article
- Article
- Associations of physical activity intensity, frequency, duration, and volume with the incidence of sarcopenia in middle-aged and older adults: a 4-year longitudinal study in China.BMC geriatrics · 2024Article
- One Year of Heavy Resistance Training Modifies Muscle Fiber Characteristics in the Elderly.Sports medicine international open · 2024Article
- Heavy resistance training at retirement age induces 4-year lasting beneficial effects in muscle strength: a long-term follow-up of an RCT.BMJ open sport & exercise medicine · 2024Article
- The Importance of Physical Activity in Preventing Fatigue and Burnout in Healthcare Workers.Healthcare (Basel, Switzerland) · 2023Article
- Relationships between anthropometric and body composition characteristics and age in Polish women over 60 as affected by their socioeconomic and health status and physical activity levels.Frontiers in physiology · 2023Article
- Computed Tomography-Derived Skeletal Muscle Radiodensity Predicts Peak Weight-Corrected Jump Power in Older Adults: The Korean Urban Rural Elderly (KURE) Study.Calcified tissue international · 2021Article
- Sarcopenia: Molecular Pathways and Potential Targets for Intervention.International journal of molecular sciences · 2020Review
- Effects of Progressive Resistance Training on Cognition and IGF-1 Levels in Elder Women Who Live in Areas with High Air Pollution.International journal of environmental research and public health · 2020Article
- Measurement of Uncertainty Using Standardized Protocol of Hand Grip Strength Measurement in Patients with Sarcopenia.Journal of bone metabolism · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPhysical and cognitive function decline with age, accelerating during the 6th decade. Loss of muscle power (force×velocity product) is a dominant physical determinant for loss of functional ability, especially if the lower extremities are affected. Muscle strength training is known to maintain or even improve muscle power as well as physical function in older adults, but the optimal type of training for beneficial long-term training effects over several years is unknown. Moreover, the impact of muscle strength training on cognitive function and brain structure remains speculative. The primary aim of this randomised controlled trial is to compare the efficacy of two different 1 year strength training regimens on immediate and long-lasting improvements in muscle power in retirement-age individuals. Secondary aims are to evaluate the effect on muscle strength, muscle mass, physical and cognitive function, mental well-being, health-related quality of life and brain morphology. METHODS AND ANALYSIS: The study includes 450 home-dwelling men and women (62-70 years). Participants are randomly allocated to (1) 1 year of supervised, centre-based heavy resistance training, (2) home-based moderate intensity resistance training or (3) habitual physical activity (control). Changes in primary (leg extensor power) and secondary outcomes are analysed according to the intention to treat principle and per protocol at 1, 2, 4, 7 and 10 years. ETHICS AND DISSEMINATION: The study is expected to generate new insights into training-induced promotion of functional ability and independency after retirement and will help to formulate national recommendations regarding physical activity schemes for the growing population of older individuals in western societies. Results will be published in scientific peer-reviewed journals, in PhD theses and at public meetings. The study is approved by the Regional Ethical Committee (Capital Region, Copenhagen, Denmark, number H-3-2014-017). TRIAL REGISTRATION NUMBER: NCT02123641.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.