ReviewHematology. American Society of Hematology. Education Program2016
The post-thrombotic syndrome.
Review in Hematology. American Society of Hematology. Education Program, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- A systematic review evaluating imaging techniques to determine chronicity of deep vein thrombosis.Phlebology · 2026Pooled it
- Effectiveness of long-term graduated compression stockings after deep vein thrombosis: a GRADE-based meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Association of post-thrombotic syndrome with metabolic syndrome and inflammation - a systematic review.Frontiers in immunology · 2025Pooled it
- Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of deep vein thrombosis.The Cochrane database of systematic reviews · 2023Pooled it
- Venous thromboembolism after arthroscopic shoulder surgery: a systematic review.Journal of orthopaedic surgery and research · 2023Pooled it
- Compression therapy for treating post-thrombotic syndrome.The Cochrane database of systematic reviews · 2019Pooled it
- Circulating microRNA expression and their target genes in deep vein thrombosis: A systematic review and bioinformatics analysis.Medicine · 2017Pooled it
- Percutaneous management of post-thrombotic syndrome: Early experience with a novel thrombectomy catheter designed to address chronic venous occlusions.Journal of vascular surgery cases and innovative techniques · 2026Article
- Plasma Metabolomics of Thrombectomy-Treated Patients Highlights Metabolic Pathways Underlying Disease and Recovery.CNS neuroscience & therapeutics · 2026Article
- Emerging strategies in venous thromboembolism: a narrative review of pharmacological innovations.Thrombosis journal · 2026Review
- [Postthrombotic syndrome: an update].Dermatologie (Heidelberg, Germany) · 2026Article
- Article
- Venous Thromboembolism and Gut Dysbiosis: Mechanistic Links Between Endotoxemia, Microbial Metabolites, and Thromboinflammation.Nutrients · 2026Review
- Exploring intermittent pneumatic compression parameters to optimize venous peak velocity and flow duration.Scientific reports · 2026Article
- Patterns of presentation of suspected and confirmed recurrent venous thromboembolism in patients with prior venous thromboembolism.Research and practice in thrombosis and haemostasis · 2026Observational
- An Overview of Anticoagulant Drugs Pharmacology, Therapeutic Approaches, Limitations and Perspectives.Pharmaceutics · 2026Review
- Machine learning-based prediction of post-thrombotic syndrome in unprovoked lower extremity deep vein thrombosis: a two-center study incorporating uric acid and clinical risk factors.European journal of medical research · 2026Article
- Plasma Level of Human Epididymis Protein 4 and Risk of Recurrence after First Venous Thromboembolism: The HUNT Study.TH open : companion journal to thrombosis and haemostasis · 2026Article
- ThrombUS+ Project: Toward Wearable Continuous Point-of-Care Monitoring for Deep Vein Thrombosis of the Lower Limb.Computational and structural biotechnology journal · 2026Article
- Comparative effectiveness of tirzepatide versus GLP-1 receptor agonists on the risk of venous thromboembolism in patients with obesity: a real-world cohort study.Frontiers in medicine · 2026Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The post-thrombotic syndrome (PTS) is a frequent, sometimes disabling complication of deep vein thrombosis (DVT) that reduces quality of life and is costly. This article discusses risk factors for PTS after DVT and available means to prevent and treat PTS, with a focus on new information in the field. After DVT, PTS will develop in 20% to 50% of patients, and severe PTS, including venous ulcers, will develop in 5% to 10%. The principal risk factors for PTS are anatomically extensive DVT, recurrent ipsilateral DVT, persistent leg symptoms 1 month after acute DVT, obesity, and older age. By preventing the initial DVT and ipsilateral DVT recurrence, primary and secondary prophylaxes of DVT will prevent cases of PTS. Based on recent evidence from a large multicenter trial, routine use of elastic compression stockings (ECS) after DVT to prevent PTS is not advocated, but in patients with DVT-related leg swelling that is bothersome, a trial of ECS is reasonable. Selecting DVT patients for catheter-directed thrombolytic treatment as a means of preventing PTS should be done on a case-by-case basis, with a focus on patients with extensive thrombosis, recent symptoms onset, and low bleeding risk. For patients with established PTS, daily use of ECS may help to relieve symptoms and edema. Intermittent compression devices can be tried in patients with moderate-to-severe PTS whose symptoms are inadequately controlled with ECS alone. A supervised exercise training program may improve PTS symptoms. Management of post-thrombotic ulcers should ideally involve a multidisciplinary approach. Important areas for future research are summarized.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.