Evidence map›Paper›PMID 27913427›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Intermittent hypoxia during recovery from neonatal hyperoxic lung injury causes long-term impairment of alveolar development: A new rat model of BPD.

Anastasiya Mankouski, Crystal Kantores, Mathew J Wong, Julijana Ivanovska, Amish Jain, Eric J Benner, Stanley N Mason, A Keith Tanswell, Richard L Auten, Robert P Jankov

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Can Intermittent Hypoxemia Help Detect Pulmonary Hypertension in High-risk Preemies?American journal of respiratory and critical care medicine · 2023
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Enhanced epithelial sodium channel activity in neonatal Scnn1b mouse lung attenuates high oxygen-induced lung injury.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  14. Bronchopulmonary Dysplasia and Pulmonary Hypertension. The Role of Smooth MuscleAmerican journal of respiratory cell and molecular biology · 2021
    Article
  15. Review
  16. Intermittent hypoxia and bronchial hyperreactivity.Seminars in fetal & neonatal medicine · 2020
    Review
  17. Article
  18. Vulnerability of the developing airway.Respiratory physiology & neurobiology · 2019
    Review
  19. Review
  20. Intermittent hypoxemia and oxidative stress in preterm infants.Respiratory physiology & neurobiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anastasiya MankouskiDivision of Neonatology, Department of Pediatrics, Neonatal-Perinatal Research Institute, Duke University Medical Center, Durham, North Carolina.
Crystal KantoresPhysiology & Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Mathew J WongPhysiology & Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Julijana IvanovskaPhysiology & Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Amish JainFaculty of Medicine, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; and.
Eric J BennerDivision of Neonatology, Department of Pediatrics, Neonatal-Perinatal Research Institute, Duke University Medical Center, Durham, North Carolina.
Stanley N MasonDivision of Neonatology, Department of Pediatrics, Neonatal-Perinatal Research Institute, Duke University Medical Center, Durham, North Carolina.
A Keith TanswellPhysiology & Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Richard L AutenDivision of Neonatology, Department of Pediatrics, Neonatal-Perinatal Research Institute, Duke University Medical Center, Durham, North Carolina.
Robert P JankovPhysiology & Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada; robert.jankov@sickkids.ca.

Funding

Center for Molecular &Cellular Studies of Ped DiseaseK12HD043494 · NICHD · DUKE UNIVERSITY · PI REED, ANN M. · 2003 to 2017
$5.2M
Duke Research Training Program for PediatriciansT32HD043029 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2002 to 2017
$3.7M
NICHD NIH HHS K12 HD043494NICHD NIH HHS T32 HD043029
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung injury characterized by impaired alveologenesis that may persist into adulthood. Rat models of BPD using varying degrees of hyperoxia to produce injury either cause early mortality or spontaneously recover following removal of the inciting stimulus, thus limiting clinical relevance. We sought to refine an established rat model induced by exposure to 60% O

Indexed as

AnimalsAnimals, NewbornBiomarkersBronchopulmonary DysplasiaCatalysisDisease Models, AnimalFemaleHyperoxiaHypertension, PulmonaryHypoxiaLung InjuryMaleMetalloporphyrinsPeroxynitrous AcidPhysical Conditioning, AnimalPneumonia5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chlorideBiomarkersMetalloporphyrinsPeroxynitrous Acidbronchopulmonary dysplasiachronic neonatal lung injuryoxygen toxicity, pulmonary hypertension

Identifiers

PMID27913427
PMCPMC5336579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.