ArticleMolecular and cellular neurosciences2017
Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain.
Article in Molecular and cellular neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A New Gal in Town: A Systematic Review of the Role of Galanin and Its Receptors in Experimental Pain.Cells · 2022Pooled it
- Novel Ligands for the Orphan Receptor GPR151 Modulate Morphine Action.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- Review: "The Disappointment Dilemma: Short- and Long-Term Learning From Negative Outcomes".The European journal of neuroscience · 2026Review
- Progress on Omega-3 fatty acids for the comprehensive and targeted treatment of spinal cord injury.Bone research · 2026Review
- The Orphan Receptor GPR151: Discovery, Expression, and Emerging Biological Significance.ACS chemical neuroscience · 2025Review
- Construction of a Searchable Database for Gene Expression Changes in Spinal Cord Injury Experiments.Journal of neurotrauma · 2024Article
- The role of orphan G protein-coupled receptors in pain.Heliyon · 2024Review
- Article
- New medications development for smoking cessation.Addiction neuroscience · 2023Article
- Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia.Frontiers in pharmacology · 2023Article
- Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Immortalized Dorsal Root Ganglion Neuron Cell Lines.Frontiers in cellular neuroscience · 2020Review
- Demethylation of G-Protein-Coupled Receptor 151 Promoter Facilitates the Binding of Krüppel-Like Factor 5 and Enhances Neuropathic Pain after Nerve Injury in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions.Wellcome open research · 2018Article
- Monosynaptic retrograde tracing of neurons expressing the G-protein coupled receptor Gpr151 in the mouse brain.The Journal of comparative neurology · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGpr151 is an orphan GPCR whose function is unknown. The restricted pattern of neuronal expression in the habenula, dorsal horn of the spinal cord and dorsal root ganglion plus homology with the galanin family of receptors imply a role in nociception.
resultsReal-time quantitative RT-PCR demonstrated a 49.9±2.9 fold highly significant (P<0.001) increase in Gpr151 mRNA expression in the dorsal root ganglion 7days after the spared nerve injury model of neuropathic pain. Measures of acute, inflammatory and neuropathic pain behaviours were not significantly different using separate groups of Gpr151 loss-of-function mutant mice and wild-type controls. Galanin at concentrations between 100nM and 10μM did not induce calcium signalling responses in ND7/23 cells transfected with Gpr151.
conclusionsOur results indicate that despite the very large upregulation in the DRG after a nerve injury model of neuropathic pain, the Gpr151 orphan receptor does not appear to be involved in the modulation of pain-related behaviours. Further, galanin is unlikely to be an endogenous ligand for Gpr151.
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