Evidence map›Paper›PMID 27913227›Full record

Trial reportThe lancet. HIV2017

Assisted partner services for HIV in Kenya: a cluster randomised controlled trial.

Peter Cherutich, Matthew R Golden, Beatrice Wamuti, Barbra A Richardson, Kristjana H Ásbjörnsdóttir, Felix A Otieno, Ann Ng'ang'a, Peter Maingi Mutiti, Paul Macharia, Betsy Sambai and 4 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The lancet. HIV, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01616420 (Assisted Partner Notification to Augment HIV Treatment and Prevention in Kenya), which is not on this map. Cited by 92 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 6 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01616420 nacompletednot on this map

Assisted Partner Notification to Augment HIV Treatment and Prevention in Kenya

TypeinterventionalSponsorUniversity of WashingtonRan2012 to 2015Enrolled2,424ConditionsHIVArmsAssisted-partner notification services
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 6 syntheses or guidelines pooled it, 145 citations in OpenAlex.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Peter CherutichNational AIDS/Sexually Transmitted Diseases Control Programme, Ministry of Health, Nairobi, Kenya. Electronic address: pcheru@uw.edu.
Matthew R GoldenDepartment of Medicine, University of Washington, Seattle, WA, USA.
Beatrice WamutiDepartment of Research and Training, Kenyatta National Hospital, Nairobi, Kenya.
Barbra A RichardsonDepartment of Global Health, University of Washington, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USA.
Kristjana H ÁsbjörnsdóttirDepartment of Global Health, University of Washington, Seattle, WA, USA.
Felix A OtienoDepartment of Research and Training, Kenyatta National Hospital, Nairobi, Kenya.
Ann Ng'ang'aNational AIDS/Sexually Transmitted Diseases Control Programme, Ministry of Health, Nairobi, Kenya.
Peter Maingi MutitiDepartment of Research and Training, Kenyatta National Hospital, Nairobi, Kenya.
Paul MachariaNational AIDS/Sexually Transmitted Diseases Control Programme, Ministry of Health, Nairobi, Kenya.
Betsy SambaiDepartment of Research and Training, Kenyatta National Hospital, Nairobi, Kenya.
Matt DunbarDepartment of Computer Science and Demography, University of Washington, Seattle, WA, USA.
David BukusiDepartment of Research and Training, Kenyatta National Hospital, Nairobi, Kenya.
Carey FarquharDepartment of Medicine, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
aPS Study Group
Kenyatta National Hospital · KEUniversity of Washington · USMinistry of Health · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Methods and Data CoreR24HD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI ELLIS, JOHN MARK · 2002 to 2016
$9.3M
Promoting Diversity, Equity, and Inclusivity in Research Training to Optimize HIV Prevention and TreatmentD43TW009580 · FIC · UNIVERSITY OF WASHINGTON · PI CAREY FARQUHAR, John Kinuthia · 2013 to 2026
$4.8M
Assisted Partner Notification to Augment HIV Treatment and Prevention in KenyaR01AI099974 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2012 to 2014
$2.6M
HIV-1 and Protective Immunity against Common Childhood PathogensK24AI087399 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2010 to 2014
$647k
FIC NIH HHS D43 TW009580NIAID NIH HHS K24 AI087399NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI099974
6 · The paper itself

Abstract

backgroundAssisted partner services for index patients with HIV infections involves elicitation of information about sex partners and contacting them to ensure that they test for HIV and link to care. Assisted partner services are not widely available in Africa. We aimed to establish whether or not assisted partner services increase HIV testing, diagnoses, and linkage to care among sex partners of people with HIV infections in Kenya.

methodsIn this cluster randomised controlled trial, we recruited non-pregnant adults aged at least 18 years with newly or recently diagnosed HIV without a recent history of intimate partner violence who had not yet or had only recently linked to HIV care from 18 HIV testing services clinics in Kenya. Consenting sites in Kenya were randomly assigned (1:1) by the study statistician (restricted randomisation; balanced distribution in terms of county and proximity to a city) to immediate versus delayed assisted partner services. Primary outcomes were the number of partners tested for HIV, the number who tested HIV positive, and the number enrolled in HIV care, in those who were interviewed at 6 week follow-up. Participants within each cluster were masked to treatment allocation because participants within each cluster received the same intervention. This trial is registered with ClinicalTrials.gov, number NCT01616420.

findingsBetween Aug 12, 2013, and Aug 31, 2015, we randomly allocated 18 clusters to immediate and delayed HIV assisted partner services (nine in each group), enrolling 1305 participants: 625 (48%) in the immediate group and 680 (52%) in the delayed group. 6 weeks after enrolment of index patients, 392 (67%) of 586 partners had tested for HIV in the immediate group and 85 (13%) of 680 had tested in the delayed group (incidence rate ratio 4·8, 95% CI 3·7-6·4). 136 (23%) partners had new HIV diagnoses in the immediate group compared with 28 (4%) in the delayed group (5·0, 3·2-7·9) and 88 (15%) versus 19 (3%) were newly enrolled in care (4·4, 2·6-7·4). Assisted partner services did not increase intimate partner violence (one intimate partner violence event related to partner notification or study procedures occurred in each group).

interpretationAssisted partner services are safe and increase HIV testing and case-finding; implementation at the population level could enhance linkage to care and antiretroviral therapy initiation and substantially decrease HIV transmission.

fundingNational Institutes of Health.

Indexed as

Health ServicesSexual PartnersCluster AnalysisHIV InfectionsHumansKenyaMass ScreeningSpouse AbuseYoung Adult

Identifiers

PMID27913227
PMCPMC5291815
OpenAlexW2558957888

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.