Evidence map›Paper›PMID 27912744›Full record

ArticleBMC neurology2016

Quality of life after stroke in Pakistan.

Wardah Khalid, Shafquat Rozi, Tazeen Saeed Ali, Iqbal Azam, Michael T Mullen, Saleem Illyas, Qamar Un-Nisa, Nabila Soomro, Ayeesha Kamran Kamal

Registry-linked trialAbstract read
In one paragraph

Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02351778 (Quality of Life of Stable Stroke Survivors and Their Caregivers in an Low and Middle Income Country), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02351778 completednot on this map

Quality of Life of Stable Stroke Survivors and Their Caregivers in an Low and Middle Income Country

TypeobservationalSponsorAga Khan UniversityRan2014 to 2014Enrolled350ConditionsCerebrovascular Disease
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Quality of life of stroke survivors in Africa: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Pooled it
  3. Article
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Deep brain stimulation for post-stroke rehabilitation in Pakistan.Annals of medicine and surgery (2012) · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. A scoping review on studies about the quality of life of informal caregivers of stroke survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wardah KhalidFogarty Cerebrovascular Research Fellow, The International Cerebrovascular Translational Clinical Research Training Program (Fogarty International Center, National Institutes of Health) and Aga Khan University, Karachi, Pakistan.
Shafquat RoziDepartment of Community Health Sciences, Epidemiology & Biostatistics, Director Clinical Research Track (CRT), Aga Khan University, Karachi, Pakistan.
Tazeen Saeed AliSchool of Nursing and Midwifery (SONAM), Karachi, Pakistan.
Iqbal AzamDepartment of Community Health Sciences, Aga Khan University Hospital, Karachi, Pakistan.
Michael T MullenDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.
Saleem IllyasDevelopment Centre DOW University of Health Sciences, Karachi, Pakistan.
Qamar Un-NisaDepartment of Neurology, DOW University of Health Sciences, Karachi, Pakistan.
Nabila SoomroInstitute of Physical Medicine and Rehabilitation, DOW University of Health Sciences, Karachi, Pakistan.
Ayeesha Kamran KamalThe International Cerebrovascular Translational Clinical Research Training Program, Fogarty International Center and the National Institute of Neurologic Disorders and Stroke, Aga Khan University, Stadium Road, 74800, Karachi, Pakistan. ayeesha.kamal@aku.edu.

Funding

International Cerebrovascular Translational Clinical Research Training ProgramD43TW008660 · FIC · AGA KHAN UNIVERSITY (PAKISTAN) · PI KAMAL, AYEESHA KAMRAN, SHAFQAT, SAAD · 2010 to 2014
$502k
FIC NIH HHS D43 TW008660
6 · The paper itself

Abstract

backgroundThere is very little information about the quality of life (QOL) of stroke survivors in LMIC countries with underdeveloped non communicable health infrastructures, who bear two thirds of the global stroke burden. METHODOLOGY: We used a sequential mix methods approach. First, a quantitative analytical cross-sectional study was conducted on 700 participants, who constituted 350 stroke survivor and their caregiver dyads. QOL of stroke survivor was assessed via Stroke Specific Quality of Life Scale (SSQOLS) whereas QOL of caregivers was assessed through RAND-36. In addition; we assessed complications, psychosocial and functional disability of stroke survivors. Following this quantitative survey, caregivers were qualitatively interviewed to uncover contextually relevant themes that would evade quantitative surveys. Multiple linear regression technique was applied to report adjusted β-coefficients with 95% C.I.

resultsThe QOL study was conducted from January 2014 till June 2014, in two large private and public centers. At each center, 175 dyads were interviewed to ensure representativeness. Median age of stroke survivors was 59(17) years, 68% were male, 60% reported depression and 70% suffered post-stroke complications. The mean SSQOLS score was 164.18 ± 32.30. In the final model severe functional disability [adjβ -33.77(-52.44, -15.22)], depression [adjβ-23.74(-30.61,-16.82)], hospital admissions [adjβ-5.51(-9.23,-1.92)] and severe neurologic pain [adjβ -12.41(-20.10,-4.77)] negatively impacted QOL of stroke survivors (P < 0.01). For caregivers, mean age was 39.18 ± 13.44 years, 51% were female and 34% reported high stress levels. Complementary qualitative study revealed that primary caregivers were depressed, frustrated, isolated and also disappointed by health services.

conclusionThe QOL of Stroke survivors as reported by SSQOLS score was better than compared to those reported from other LMIC settings. However, Qualitative triangulation revealed that younger caregivers felt isolated, depressed, overwhelmed and were providing care at great personal cost. There is a need to develop cost effective holistic home support interventions to improve lives of the survivor dyad as a unit.

trial registrationNCT02351778 (Registered as Observational Study).

Indexed as

AdultAgedCaregiversCross-Sectional StudiesDepressionFemaleHospitalizationHumansMaleMiddle AgedPakistanQuality of LifeStrokeSurveys and QuestionnairesSurvivorsChronic DiseaseComplicationsEpidemiologyFGD`S (Focus group discussion) Sequential Mix MethodsLMIC (Lower middle income country)Post-stroke depressionStroke Specific Quality of life scale (SSQOLS)Triangulation

Identifiers

PMID27912744
PMCPMC5135839

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.