ArticleJournal of neurotrauma2017
Sex and Age Differences in Epinephrine Mechanisms and Outcomes after Brain Injury.
Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Article
- Article
- Differential Hemodynamic Response of Pial Arterioles Contributes to a Quadriphasic Cerebral Autoregulation Physiology.Journal of the American Heart Association · 2022Article
- Localization of the hydrogen sulfide and oxytocin systems at the depth of the sulci in a porcine model of acute subdural hematoma.Neural regeneration research · 2021Review
- Regulation of the Cerebral Circulation During Development.Comprehensive Physiology · 2021Article
- KRSA: An R package and R Shiny web application for an end-to-end upstream kinase analysis of kinome array data.PloS one · 2021Article
- Improving Understanding and Outcomes of Traumatic Brain Injury Using Bidirectional Translational Research.Journal of neurotrauma · 2020Review
- Updating the risk profile of fatal head trauma: an autopsy study with focus on age- and sex-dependent differences.International journal of legal medicine · 2020Article
- Autoregulation assessment by direct visualisation of pial arterial blood flow in the piglet brain.Scientific reports · 2019Article
- Translational approach towards determining the role of cerebral autoregulation in outcome after traumatic brain injury.Experimental neurology · 2019Review
- Sex differences in pediatric traumatic brain injury.Experimental neurology · 2019Review
- Sex Differences in Acute Neuroinflammation after Experimental Traumatic Brain Injury Are Mediated by Infiltrating Myeloid Cells.Journal of neurotrauma · 2019Article
- Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK.Translational stroke research · 2019Article
- Sex Differences in Animal Models of Traumatic Brain Injury.Journal of experimental neuroscience · 2019Review
- The potential roles of dopamine in traumatic brain injury: a preclinical and clinical update.American journal of translational research · 2019Review
- Neonatal cerebrovascular autoregulation.Pediatric research · 2018Review
- K channel impairment determines sex and age differences in epinephrine-mediated outcomes after brain injury.Journal of neuroscience research · 2017Article
- Dopamine protects cerebral autoregulation and prevents hippocampal necrosis after traumatic brain injury via block of ERK MAPK in juvenile pigs.Brain research · 2017Article
- Clinical profile and comorbidity of traumatic brain injury among younger and older men and women: a brief research notes.BMC research notes · 2017Article
Corrections and comments
- Retraction · 2022-04-29Author Unresponsive · Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · · William Armstead has ORI finding of misconduct; see https://ori.hhs.gov/content/case-summary-armstead-william-m
- Commented on by
- Retracted
Authors and funding
3 authors.
Funding
Abstract
Traumatic brain injury (TBI) is the leading cause of injury-related death in children, with boys and children <4 years of age having particularly poor outcomes. Cerebral autoregulation is often impaired after TBI, contributing to poor outcome. Cerebral perfusion pressure can be normalized by use of vasoactive agents. The c-Jun-terminal kinase (JNK) isoform of mitogen activated protein kinase (MAPK) produces hemodynamic impairment after TBI, but less is known about its role in histopathology. We investigated whether epinephrine (EPI), age, and sex dependently protected cerebral autoregulation and limited histopathology after TBI, and sought to determine the role of JNK in that outcome. Lateral fluid percussion injury (FPI) was produced in anesthetized pigs. Pial artery reactivity was measured via a closed cranial window. Phosphorylated JNK MAPK was quantified by enzyme-linked immunosorbent assay (ELISA). Results show that EPI preserves autoregulation, prevents histopathology, and blocks phosphorylated JNK upregulation in newborn males and females and juvenile females but not juvenile males after TBI. These data indicate that EPI preserves cerebral autoregulation and limits histopathology after TBI through blockade of JNK in an age- and sex-dependent manner.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.