Evidence map›Paper›PMID 27912089›Full record

ArticleCell stem cell2016

Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny.

Purushothama Rao Tata, Jayaraj Rajagopal

Abstract read
In one paragraph

Article in Cell stem cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Unlocking the Potential of Stem Cell Microenvironments In Vitro.Bioengineering (Basel, Switzerland) · 2024
    Review
  4. Transit Amplifying Cells (TACs): a still not fully understood cell population.Frontiers in bioengineering and biotechnology · 2023
    Review
  5. Article
  6. Tissue Homeostasis and Non-Homeostasis: From Cell Life Cycles to Organ States.Annual review of cell and developmental biology · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  12. Article
  13. Article
  14. Plasticity in the lung: making and breaking cell identity.Development (Cambridge, England) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Purushothama Rao TataCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Jayaraj RajagopalCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA 02114, USA; Division of Otology and Laryngology, Massachusetts Eye and Ear, Boston, MA 02114, USA. Electronic address: jrajagopal@mgh.harvard.edu.

Funding

Intercellular communication and cell regulation in airway epithelial ensembles in regeneration and diseaseR01HL118185 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RAJAGOPAL, JAYARAJ · 2014 to 2021
$4.2M
Defining the role of Hippo signaling in airway injury repair and remodelingR01HL116756 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RAJAGOPAL, JAYARAJ · 2013 to 2017
$2.2M
To define the role of SOX9 and Sox9+ cells in alveolar homeostasis and regenerationR00HL127181 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2017 to 2019
$738k
To define the role of SOX9 and Sox9+ cells in alveolar homeostasis and regenerationK99HL127181 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI TATA, PURUSHOTHAMA RAO · 2015 to 2016
$273k
NHLBI NIH HHS K99 HL127181NHLBI NIH HHS R00 HL127181NHLBI NIH HHS R01 HL116756NHLBI NIH HHS R01 HL118185
6 · The paper itself

Abstract

Feedback signals from daughter cells to stem cells are well studied and known to provide important feedback cues. Emerging evidence shows that stem cells also send feedforward signals to their progeny. Complex circuits involving both negative and positive feedback and feedforward signals likely contribute to robust tissue maintenance and regeneration.

Indexed as

Signal TransductionAnimalsAutocrine CommunicationCell LineageFeedback, PhysiologicalHumansModels, BiologicalStem Cells

Identifiers

PMID27912089
PMCPMC5677519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.