Evidence map›Paper›PMID 27912086›Full record

ArticleCell stem cell2016

The Mediator of Hematopoietic Stem Cell Homeostasis.

Sneha Borikar, Jennifer J Trowbridge

Abstract readComment
In one paragraph

Article in Cell stem cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sneha BorikarThe Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME 04609, USA.
Jennifer J TrowbridgeThe Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME 04609, USA. Electronic address: jennifer.trowbridge@jax.org.

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
(PQB5) Epigenetic Drivers of Hematopoietic Stem Cell TransformationR21CA184851 · NCI · JACKSON LABORATORY · PI TROWBRIDGE, JENNIFER JEAN · 2014 to 2015
$426k
NCI NIH HHS P30 CA034196NCI NIH HHS R21 CA184851
6 · The paper itself

Abstract

Mechanisms establishing and maintaining promoter-enhancer interactions in hematopoietic stem cells (HSCs) to maintain stem cell identity are not fully understood. In this issue of Cell Stem Cell, Aranda-Orgilles et al. (2016) describe a role for a member of the Mediator complex in maintaining HSC-specific enhancers and hematopoietic homeostasis.

Indexed as

Hematopoietic Stem CellsHomeostasisHumans

Identifiers

PMID27912086
PMCPMC6547814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.