Evidence map›Paper›PMID 27911979›Full record

ArticleCancer2017

Clinicopathological features and clinical outcomes associated with TP53 and BRAF

Dae Won Kim, Lauren E Haydu, Aron Y Joon, Roland L Bassett, Alan E Siroy, Michael T Tetzlaff, Mark J Routbort, Rodabe N Amaria, Jennifer A Wargo, Jennifer L McQuade and 8 more

Abstract read
In one paragraph

Article in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Follicular cell-derived thyroid carcinomas harboring novel geneticArchives of endocrinology and metabolism · 2024
    Article
  6. Article
  7. Unique Spectrum of Activating BRAF Alterations in Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  8. Targeted Therapy for Melanomas Without BRAF V600 Mutations.Current treatment options in oncology · 2022
    Review
  9. Article
  10. Article
  11. Review
  12. Management ofFrontiers in oncology · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Targeted Therapy in Advanced Melanoma With RareJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019
    Article
  17. Article
  18. Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib-treated Patients withClinical cancer research : an official journal of the American Association for Cancer Research · 2019
    Article
  19. Targeting the ERK Signaling Pathway in Melanoma.International journal of molecular sciences · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Dae Won KimDepartment of Medical Oncology, Moffitt Cancer Center, Tampa, Florida.
Lauren E HayduDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Aron Y JoonDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Roland L BassettDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Alan E SiroyDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Michael T TetzlaffDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Mark J RoutbortDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Rodabe N AmariaDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jennifer A WargoDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jennifer L McQuadeDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jan KemnadeDepartment of Internal Medicine, Baylor College of Medicine, Houston, Texas.
Patrick HwuDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Scott E WoodmanDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jason RoszikDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Kevin B KimMelanoma Clinical Research Program, California Pacific Medical Center, San Francisco, California.
Jeffrey E GershenwaldDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Alexander J LazarDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Michael A DaviesDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
The University of Texas MD Anderson Cancer Center · USBaylor College of Medicine · USMoffitt Cancer Center · USNorthern California Melanoma Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
UT M.D. Anderson Cancer Center SPORE in MelanomaP50CA093459 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GRIMM, ELIZABETH A · 2004 to 2014
$23.7M
TRAINING FOR ACADEMIC ONCOLOGY/HEMATOLOGYT32CA009666 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Michael Davies, Courtney DiNardo · 1994 to 2026
$9.8M
The role of the PI3K pathway in immune resistanceR01CA187076 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DAVIES, MICHAEL, HWU, PATRICK · 2014 to 2018
$2.0M
Multidisciplinary Subspecialty Pathology Research Fellowship ProgramT32CA163185 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CZERNIAK, BOGDAN A, KEYOMARSI, KHANDAN · 2011 to 2015
$1.7M
The Role of the PI3K-AKT Pathway in Melanoma Brain MetastasisR01CA154710 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DAVIES, MICHAEL · 2011 to 2015
$1.6M
Exploring synergy of combined BRAF-targeted therapy & immunotherapy for melanomaK08CA160692 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WARGO, JENNIFER A. · 2012 to 2016
$713k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K08 CA160692NCI NIH HHS P50 CA093459NCI NIH HHS R01 CA154710NCI NIH HHS R01 CA187076NCI NIH HHS T32 CA009666NCI NIH HHS T32 CA163185
6 · The paper itself

Abstract

backgroundBRAF

methodsThis study analyzed the patient demographics, primary tumor features, and clinical outcomes of a large cohort of non-acral cutaneous melanoma patients who had undergone clinically indicated molecular testing (n = 926).

resultsThe prevalence of BRAF

conclusionsThese results add to the understanding of the clinical features associated with TP53 and BRAF

Indexed as

MutationAdolescentAdultAgedAged, 80 and overBiomarkers, TumorChildCutaneous Malignant MelanomaDNA Mutational AnalysisFemaleHumansKaplan-Meier EstimateMaleMelanomaMiddle AgedMolecular Targeted TherapyBiomarkers, TumorProtein Kinase InhibitorsProto-Oncogene Proteins B-rafTumor Suppressor Protein p53BRAFNon-V600BRAFV600melanomamutationsTP53

Identifiers

PMID27911979
PMCPMC5384865
OpenAlexW2560709471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.