Trial reportPloS one2016
Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Copper, Zinc, and Selenium Levels During Pregnancy and Their Relationship with Pre-Eclampsia Risk: A Systematic Review.Nutrients · 2025Pooled it
- Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Effects of prenatal micronutrients supplementation timing on pregnancy-induced hypertension: Secondary analysis of a double-blind randomized controlled trial.Maternal & child nutrition · 2021Trial
- Maternal and Umbilical Cord Blood Levels of Lead and Cadmium in Sudanese Women with Preeclampsia.Journal of clinical medicine · 2026Article
- Serum Magnesium and Zinc Levels in Pregnant Women with Preeclampsia Compared to Healthy Controls: Case-Control Study.Biological trace element research · 2026Article
- Levels of Cu, Zn, and Se in Maternal and Cord Blood in Normal and Pathological Pregnancies: A Narrative Review.International journal of molecular sciences · 2025Review
- Strong association between hypocalcemia and preeclampsia-eclampsia among pregnant women attending at a tertiary referral hospital in Northwestern Tanzania.Scientific reports · 2025Article
- Maternal Metal Ion Status Along Pregnancy and Perinatal Outcomes in a Group of Mexican Women.International journal of molecular sciences · 2024Article
- Longitudinal Assessment of Calcium and Magnesium Levels in Women with Preeclampsia.Biological trace element research · 2023Observational
- Serum Calcium and Magnesium Levels in Women Presenting with Pre-eclampsia: A Systematic Review and Meta-analysis Based on Observational Studies.Galen medical journal · 2023Review
- Maternal nutritional risk factors for pre-eclampsia incidence: findings from a narrative scoping review.Reproductive health · 2022Article
- Association of dietary calcium intake, total and ionized serum calcium levels with preeclampsia in Ethiopia.BMC pregnancy and childbirth · 2021Article
- Association between breastfeeding and preeclampsia in parous women: a case -control study.International breastfeeding journal · 2021Article
- Serum magnesium and calcium in preeclampsia: a comparative study at the Korle-Bu Teaching Hospital, Ghana.Integrated blood pressure control · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the exact pathophysiology of preeclampsia is not fully understood, several elemental micronutrient abnormalities have been suggested to play a contributory role in preeclampsia.
aimsTo investigate the levels of calcium, magnesium, zinc and copper in women with preeclampsia. SUBJECTS AND
methodsA case-control study was conducted in Omdurman Maternity Hospital, Sudan, during the period of September through December 2014. The cases were women with preeclampsia while healthy pregnant women were the controls. The medical and obstetrics history was gathered using questionnaires. The serum levels of calcium, magnesium, zinc and copper were measured using atomic absorption spectrophotometer.
resultsThere was no significant difference between the two groups in their age, gestational age, parity and body mass index. Zinc and copper levels were not significantly different between the two groups. In comparison with the controls, women with preeclampsia had a significantly lower median (inter-quartile) serum calcium [7.6 (4.0─9.6) vs. 8.1 (10.6─14.2), mg/dl, P = 0.032] and higher levels of magnesium [1.9 (1.4─2.5) vs. 1.4 (1.0─1.9) mg/dl; P = 0.003]. In binary logistic regression, lower calcium (OR = 0.73, 95% CI = 0.56 ─ 0.95, P = 0.021) and higher magnesium (OR = 5.724, 95% CI = 1.23 ─ 26.50, P = 0.026) levels were associated with preeclampsia. There were no significant correlations between levels of hemoglobin and these trace elements.
conclusionThe current study showed significant associations between preeclampsia and serum levels of calcium and magnesium.
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