ArticleProceedings of the National Academy of Sciences of the United States of America2016
Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Genomics of host-microbiome interactions in humans.Nature reviews. Genetics · 2026Review
- Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling.Mucosal immunology · 2025Article
- Integrated ATAC-seq and RNA-seq analysis identifies key regulatory elements in NK cells activated with feeder cells and IL-2.Bioengineering & translational medicine · 2025Article
- Review
- Epigenetics and environmental health.Frontiers of medicine · 2024Review
- Interplay between Microbiota and γδ T Cells: Insights into Immune Homeostasis and Neuro-Immune Interactions.International journal of molecular sciences · 2024Review
- The coral microbiome: towards an understanding of the molecular mechanisms of coral-microbiota interactions.FEMS microbiology reviews · 2023Article
- T Cell Responses to the Microbiota.Annual review of immunology · 2022Review
- Review
- Targeting theMolecular therapy. Methods & clinical development · 2021Article
- Extrachromosomal circular DNA: a new potential role in cancer progression.Journal of translational medicine · 2021Review
- The relationship between the gut microbiome and host gene expression: a review.Human genetics · 2021Review
- Super enhancers-Functional cores under the 3D genome.Cell proliferation · 2021Review
- Epigenome-metabolome-microbiome axis in health and IBD.Current opinion in microbiology · 2020Review
- IRF2 is a master regulator of human keratinocyte stem cell fate.Nature communications · 2019Article
- Article
- Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity.Journal of immunology research · 2019Review
- Differential Requirement ofFrontiers in immunology · 2019Article
- The elusive case of human intraepithelial T cells in gut homeostasis and inflammation.Nature reviews. Gastroenterology & hepatology · 2018Review
- The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease.Nature reviews. Nephrology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The gut microbiota impacts many aspects of host biology including immune function. One hypothesis is that microbial communities induce epigenetic changes with accompanying alterations in chromatin accessibility, providing a mechanism that allows a community to have sustained host effects even in the face of its structural or functional variation. We used Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) to define chromatin accessibility in predicted enhancer regions of intestinal αβ
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.