ArticleProceedings of the National Academy of Sciences of the United States of America2016
Map reading, navigating from maps, and the medial temporal lobe.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Developmental exposure to legacy environmental contaminants, medial temporal lobe volumes and spatial navigation memory in late adolescents.Environmental research · 2025Article
- Combining patient-lesion and big data approaches to reveal hippocampal contributions to spatial memory and navigation.iScience · 2024Article
- Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age.Neuron · 2023Review
- Largely intact memory for spatial locations during navigation in an individual with dense amnesia.Neuropsychologia · 2022Article
- Place cells may simply be memory cells: Memory compression leads to spatial tuning and history dependence.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging.Brain sciences · 2021Article
- Spared Perception of the Structure of Scenes after Hippocampal Damage.Journal of cognitive neuroscience · 2019Article
- The nature of recollection across months and years and after medial temporal lobe damage.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Neural signatures of reinforcement learning correlate with strategy adoption during spatial navigation.Scientific reports · 2018Article
- The role of the hippocampus in navigation is memory.Journal of neurophysiology · 2017Review
- Three Scientific Controversies to Engage Students in Reading Primary Literature.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2017Article
- Getting Lost Behavior in Patients with Mild Alzheimer's Disease: A Cognitive and Anatomical Model.Frontiers in medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We administered map-reading tasks in which participants navigated an array of marks on the floor by following paths on hand-held maps that made up to nine turns. The burden on memory was minimal because the map was always available. Nevertheless, because the map was held in a fixed position in relation to the body, spatial computations were continually needed to transform map coordinates into geographical coordinates as participants followed the maps. Patients with lesions limited to the hippocampus (n = 5) performed similar to controls at all path lengths (experiment 1). They were also intact at executing single moves to an adjacent location, even when trials began by facing in a direction that put the map coordinates and geographical coordinates into conflict (experiment 2). By contrast, one patient with large medial temporal lobe (MTL) lesions performed poorly overall in experiment 1 and poorly in experiment 2 when trials began by facing in the direction that placed the map coordinates and geographical coordinates in maximal conflict. Directly after testing, all patients were impaired at remembering factual details about the task. The findings suggest that the hippocampus is not needed to carry out the spatial computations needed for map reading and navigating from maps. The impairment in map reading associated with large MTL lesions may depend on damage in or near the parahippocampal cortex.
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Registered trials
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