ArticleProceedings of the National Academy of Sciences of the United States of America2016
Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Biodiversity in Urban Green Space: A Bibliometric Review on the Current Research Field and Its Prospects.International journal of environmental research and public health · 2022Pooled it
- Toward development of soil-derivedBiodesign research · 2026Article
- Discovery and Characterization of a Novel Bacteriocin PFS-3 Targeting Multidrug-Resistant Escherichia coli.Probiotics and antimicrobial proteins · 2026Article
- Exploring the antibacterial potential of environmental Pseudomonas aeruginosa isolates: Insights from in vitro studies and genome mining approaches.Journal, genetic engineering & biotechnology · 2025Article
- Article
- Metagenomic interrogation of urban Superfund site reveals antimicrobial resistance reservoir and bioremediation potential.Journal of applied microbiology · 2025Article
- Whole genome sequencing of Penicillium and Burkholderia strains antagonistic to the causal agent of kauri dieback disease (Phytophthora agathidicida) reveals biosynthetic gene clusters related to antimicrobial secondary metabolites.Molecular ecology resources · 2025Article
- Metagenomes and metagenome-assembled genomes from tidal lagoons at a New York City waterfront park.PeerJ · 2025Article
- Exploring the biosynthesis potential of permafrost microbiomes.Environmental microbiome · 2024Article
- Exploring microbial diversity and biosynthetic potential in zoo and wildlife animal microbiomes.Nature communications · 2024Article
- The impacts of ecological disturbances on the diversity of biosynthetic gene clusters in kauri (Agathis australis) soil.Environmental microbiome · 2024Article
- SecMet-FISH: labeling, visualization, and enumeration of secondary metabolite producing microorganisms.FEMS microbiology ecology · 2024Article
- Succession of microbial community composition and secondary metabolism during marine biofilm development.ISME communications · 2024Article
- Novel Gene Clusters for Natural Product Synthesis Are Abundant in the Mangrove Swamp Microbiome.Applied and environmental microbiology · 2023Article
- Strategies to access biosynthetic novelty in bacterial genomes for drug discovery.Nature reviews. Drug discovery · 2022Review
- The Bacterial Urban Resistome: Recent Advances.Antibiotics (Basel, Switzerland) · 2022Review
- Combined assembly of long and short sequencing reads improve the efficiency of exploring the soil metagenome.BMC genomics · 2022Article
- Old and modern antibiotic structures with potential for today's infections.ADMET & DMPK · 2022Review
- The natural product biosynthesis potential of the microbiomes of Earth - Bioprospecting for novel anti-microbial agents in the meta-omics era.Computational and structural biotechnology journal · 2022Review
- Secondary metabolite biosynthetic diversity in Arctic Ocean metagenomes.Microbial genomics · 2021Article
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12 authors at 3 institutions in 1 country.
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Abstract
Numerous therapeutically relevant small molecules have been identified from the screening of natural products (NPs) produced by environmental bacteria. These discovery efforts have principally focused on culturing bacteria from natural environments rich in biodiversity. We sought to assess the biosynthetic capacity of urban soil environments using a phylogenetic analysis of conserved NP biosynthetic genes amplified directly from DNA isolated from New York City park soils. By sequencing genes involved in the biosynthesis of nonribosomal peptides and polyketides, we found that urban park soil microbiomes are both rich in biosynthetic diversity and distinct from nonurban samples in their biosynthetic gene composition. A comparison of sequences derived from New York City parks to genes involved in the biosynthesis of biomedically important NPs produced by bacteria originally collected from natural environments around the world suggests that bacteria producing these same families of clinically important antibiotics, antifungals, and anticancer agents are actually present in the soils of New York City. The identification of new bacterial NPs often centers on the systematic exploration of bacteria present in natural environments. Here, we find that the soil microbiomes found in large cities likely hold similar promise as rich unexplored sources of clinically relevant NPs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.