Evidence map›Paper›PMID 27911806›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Permissive roles of cytokines interleukin-7 and Flt3 ligand in mouse B-cell lineage commitment.

Lilly von Muenchow, Llucia Alberti-Servera, Fabian Klein, Giuseppina Capoferri, Daniela Finke, Rhodri Ceredig, Antonius Rolink, Panagiotis Tsapogas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. The role of GATA2 in adult hematopoiesis and cell fate determination.Frontiers in cell and developmental biology · 2023
    Review
  3. Article
  4. Flt3 Signaling in B Lymphocyte Development and Humoral Immunity.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Article
  7. Modeling the Hematopoietic Landscape.Frontiers in cell and developmental biology · 2019
    Review
  8. Article
  9. Review
  10. Molecular Regulation of Differentiation in Early B-Lymphocyte Development.International journal of molecular sciences · 2018
    Review
  11. Article
  12. Article
  13. Article
  14. The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis.International journal of molecular sciences · 2017
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lilly von MuenchowDevelopmental and Molecular Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.
Llucia Alberti-ServeraDevelopmental and Molecular Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.
Fabian KleinDevelopmental and Molecular Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.
Giuseppina CapoferriDevelopmental and Molecular Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.
Daniela FinkeResearch Department, University Children's Hospital Basel, 4056 Basel, Switzerland.
Rhodri CeredigDiscipline of Physiology, National University of Ireland, H91 DK59 Galway, Ireland.
Antonius RolinkDevelopmental and Molecular Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.
Panagiotis TsapogasDevelopmental and Molecular Immunology, Department of Biomedicine, University of Basel, 4058 Basel, Switzerland; panagiotis.tsapogas@unibas.ch.ORCID 0000-0002-9450-2604
University of Basel · CHNational University of Ireland · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic cells are continuously generated throughout life from hematopoietic stem cells, thus making hematopoiesis a favorable system to study developmental cell lineage commitment. The main factors incorporating environmental signals to developing hematopoietic cells are cytokines, which regulate commitment of hematopoietic progenitors to the different blood lineages by acting either in an instructive or a permissive manner. Fms-like tyrosine kinase-3 (Flt3) ligand (FL) and Interleukin-7 (IL-7) are cytokines pivotal for B-cell development, as manifested by the severely compromised B-cell development in their absence. However, their precise role in regulating B-cell commitment has been the subject of debate. In the present study we assessed the rescue of B-cell commitment in mice lacking IL-7 but simultaneously overexpressing FL. Results obtained demonstrate that FL overexpression in IL-7-deficient mice rescues B-cell commitment, resulting in significant Ebf1 and Pax5 expression in Ly6D

Indexed as

AnimalsAntigens, CD19Antigens, LyB-LymphocytesCell LineageCell ProliferationCell SurvivalFemaleGPI-Linked ProteinsHematopoiesisHematopoietic Stem CellsInterleukin-7Lymphoid Progenitor CellsMaleMembrane ProteinsMiceAntigens, CD19Antigens, LyCD19 antigen, mouseflt3 ligand proteinGPI-Linked ProteinsInterleukin-7Ly6d protein, mouseMembrane Proteinscommitmentcytokineshematopoiesisimmunology

Identifiers

PMID27911806
PMCPMC5167207
OpenAlexW2559016056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.