ArticleProceedings of the National Academy of Sciences of the United States of America2016
Mechanical bounds to transcriptional noise.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- DNA supercoiling in bacteria: state of play and challenges from a viewpoint of physics based modeling.Frontiers in microbiology · 2023Review
- Interpretable and tractable models of transcriptional noise for the rational design of single-molecule quantification experiments.Nature communications · 2022Article
- Collective polymerase dynamics emerge from DNA supercoiling during transcription.Biophysical journal · 2022Article
- Molecular Origins of Transcriptional Heterogeneity in Diazotrophic Klebsiella oxytoca.mSystems · 2022Article
- DNA supercoiling-mediated collective behavior of co-transcribing RNA polymerases.Nucleic acids research · 2022Article
- Volumetric compression develops noise-driven single-cell heterogeneity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Can Systems Biology Advance Clinical Precision Oncology?Cancers · 2021Review
- A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions.Science (New York, N.Y.) · 2021Article
- A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells.PloS one · 2021Article
- Reconciling kinetic and thermodynamic models of bacterial transcription.PLoS computational biology · 2021Article
- A Mechanochemical Model of Transcriptional Bursting.Biophysical journal · 2020Article
- Properties of gene expression and chromatin structure with mechanically regulated elongation.Nucleic acids research · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past several decades it has been increasingly recognized that stochastic processes play a central role in transcription. Although many stochastic effects have been explained, the source of transcriptional bursting (one of the most well-known sources of stochasticity) has continued to evade understanding. Recent results have pointed to mechanical feedback as the source of transcriptional bursting, but a reconciliation of this perspective with preexisting views of transcriptional regulation is lacking. In this article, we present a simple phenomenological model that is able to incorporate the traditional view of gene expression within a framework with mechanical limits to transcription. By introducing a simple competition between mechanical arrest and relaxation copy number probability distributions collapse onto a shared universal curve under shifting and rescaling and a lower limit of intrinsic noise for any mean expression level is found.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.