ArticleProceedings of the National Academy of Sciences of the United States of America2016
Siderophore-based microbial adaptations to iron scarcity across the eastern Pacific Ocean.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 222 citations in OpenAlex.
- Differences in Siderophore Production During the Growth of Phytoplankton in Southern Ocean Incubation Experiments Under High- and Low-Iron Conditions.Environmental microbiology · 2026Article
- Re-examining the iron paradox: the influence of growth medium on regulation and functionality of the tropodithietic acid (TDA) biosynthetic pathway in Phaeobacter piscinae.FEMS microbiology ecology · 2026Article
- Kineochelins-A New Group of Siderophores From an Antarctic Bacterium.Microbial biotechnology · 2026Article
- Iron availability modulates bacteria carbon cycling in the mesopelagic.Scientific reports · 2026Article
- Genomic and Functional Diversity of Pseudoalteromonas Associated with the Tropical Bivalve Anadara tuberculosa.Microbial ecology · 2026Article
- Bacterial iron acquisition byProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Contrasting bioavailability of enterobactin- and ferrichrome-bound iron to SAR11 and other marine heterotrophs.ISME communications · 2026Article
- Structures and broad-spectrum growth-inhibiting activity of formomarinobactin, formylated marinobactin analogs from theFrontiers in microbiology · 2026Article
- Computational mass spectrometry and genome mining guided discovery of metallophores produced by Microbulbifer.ISME communications · 2026Article
- Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish (Aphanius dispar) infection.Communications biology · 2025Article
- Overlooked siderophore producers favor ammonium oxidation in global wastewater treatment plants.Microbiome · 2025Article
- Metagenomic Profiling and Genome-Centric Analysis Reveal Iron Acquisition Systems in Cheese-Associated Bacteria and Fungi.Environmental microbiology · 2025Article
- Exploring the potential of repurposed deferoxamine: bridging challenges and novel formulation opportunities.Nanomedicine (London, England) · 2025Review
- Genetic and biochemical insights into siderophore biosynthesis in the marine fish pathogen Tenacibaculum maritimum.Scientific reports · 2025Article
- Discovery of Peptidic Siderophore Degradation by Screening Natural Product Profiles in Marine-Derived Bacterial Mono- and Cocultures.Biochemistry · 2025Article
- Iron limitation triggers roseoceramide biosynthesis and membrane remodeling in marine roseobacter.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Response of marine microbes to iron contained in colloids of glacial origin: a Kerguelen Island case study.ISME communications · 2025Article
- Probiotic paradox: bacillibactin fromISME communications · 2025Article
- Article
- A Practical Toolkit for the Detection, Isolation, Quantification, and Characterization of Siderophores and Metallophores in Microorganisms.ACS omega · 2024Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nearly all iron dissolved in the ocean is complexed by strong organic ligands of unknown composition. The effect of ligand composition on microbial iron acquisition is poorly understood, but amendment experiments using model ligands show they can facilitate or impede iron uptake depending on their identity. Here we show that siderophores, organic compounds synthesized by microbes to facilitate iron uptake, are a dynamic component of the marine ligand pool in the eastern tropical Pacific Ocean. Siderophore concentrations in iron-deficient waters averaged 9 pM, up to fivefold higher than in iron-rich coastal and nutrient-depleted oligotrophic waters, and were dominated by amphibactins, amphiphilic siderophores with cell membrane affinity. Phylogenetic analysis of amphibactin biosynthetic genes suggests that the ability to produce amphibactins has transferred horizontally across multiple Gammaproteobacteria, potentially driven by pressures to compete for iron. In coastal and oligotrophic regions of the eastern Pacific Ocean, amphibactins were replaced with lower concentrations (1-2 pM) of hydrophilic ferrioxamine siderophores. Our results suggest that organic ligand composition changes across the surface ocean in response to environmental pressures. Hydrophilic siderophores are predominantly found across regions of the ocean where iron is not expected to be the limiting nutrient for the microbial community at large. However, in regions with intense competition for iron, some microbes optimize iron acquisition by producing siderophores that minimize diffusive losses to the environment. These siderophores affect iron bioavailability and thus may be an important component of the marine iron cycle.
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