ArticleProceedings of the National Academy of Sciences of the United States of America2016
Optical magnetic detection of single-neuron action potentials using quantum defects in diamond.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 122 papers.
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Who cites it
122 citing papers in PubMed.
- Quantum dot sensors for heavy metal detection: from mechanistic design to field deployment: a review.RSC advances · 2026Review
- Optical Detection of Cellular Signals at Material Interfaces.Advanced healthcare materials · 2026Review
- In vivo magnetic recording of neuronal action potentials using a differential TMR magnetrode.Microsystems & nanoengineering · 2026Article
- Opportunities for Quantum Sensing in Epilepsy Diagnostics.Sensors (Basel, Switzerland) · 2026Review
- Potential Effect of Magnetic Field onInsects · 2026Article
- Magnetometry for Agriculture and Animal Systems: From Classical Sensors to Quantum-Enabled Biosensing.Biosensors · 2026Review
- Experimental Quantification of Spin-Phonon Coupling in Molecular Qubits Using Inelastic Neutron Scattering.Journal of the American Chemical Society · 2026Article
- An advanced TMR sensor-based magnetrode for in vivo LFP magnetic field recording.Microsystems & nanoengineering · 2026Article
- Spatial richness of neural magnetic fields.PLoS computational biology · 2026Article
- Optically assigned vector magnetometry with nitrogen-vacancy center ensembles in diamond via polarization anisotropy.Scientific reports · 2026Article
- Magnetic field based investigation of Brugada syndrome.European biophysics journal : EBJ · 2026Article
- Multimodal Super-Resolution Imaging of Nitrogen-Vacancy Centers via High-Index-Induced Structured Illumination Microscopy and Optically Detected Magnetic Resonance Spectrometry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Quantum Sensing MRI for Noninvasive Detection of Neuronal Electrical Activity in Human Brains.ArXiv · 2026Article
- Zero- to ultralow-field J-spectroscopy with a diamond magnetometer.Communications chemistry · 2026Article
- Probing Cellular Activity Via Charge-Sensitive Quantum Nanoprobes.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Progress in Clinical Magnetocardiography: The Contactless Breakthrough for Noninvasive Clinical Detection of Cardiac Ischemia Now Needs Worldwide Standardization.Sensors (Basel, Switzerland) · 2026Review
- Chemically Resolved Nuclear Magnetic Resonance Spectroscopy by Longitudinal Magnetization Detection with a Diamond Magnetometer.ACS measurement science au · 2026Article
- Plasmonic imaging of living pancreatic beta-cell networks.Scientific reports · 2026Article
- Psychedelics and the quantum brain: a falsifiable hypothesis on Posner molecules and spin-dependent pharmacology.Frontiers in pharmacology · 2026Article
- Toward Subcellular Action Potential Detection with Nanodiamond Quantum Magnetometry.Nanomaterials (Basel, Switzerland) · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic fields from neuronal action potentials (APs) pass largely unperturbed through biological tissue, allowing magnetic measurements of AP dynamics to be performed extracellularly or even outside intact organisms. To date, however, magnetic techniques for sensing neuronal activity have either operated at the macroscale with coarse spatial and/or temporal resolution-e.g., magnetic resonance imaging methods and magnetoencephalography-or been restricted to biophysics studies of excised neurons probed with cryogenic or bulky detectors that do not provide single-neuron spatial resolution and are not scalable to functional networks or intact organisms. Here, we show that AP magnetic sensing can be realized with both single-neuron sensitivity and intact organism applicability using optically probed nitrogen-vacancy (NV) quantum defects in diamond, operated under ambient conditions and with the NV diamond sensor in close proximity (∼10 µm) to the biological sample. We demonstrate this method for excised single neurons from marine worm and squid, and then exterior to intact, optically opaque marine worms for extended periods and with no observed adverse effect on the animal. NV diamond magnetometry is noninvasive and label-free and does not cause photodamage. The method provides precise measurement of AP waveforms from individual neurons, as well as magnetic field correlates of the AP conduction velocity, and directly determines the AP propagation direction through the inherent sensitivity of NVs to the associated AP magnetic field vector.
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