Evidence map›Paper›PMID 27911752›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2016

Frontosubthalamic Circuits for Control of Action and Cognition.

Adam R Aron, Damian M Herz, Peter Brown, Birte U Forstmann, Kareem Zaghloul

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adam R AronDepartment of Psychology, University of California San Diego, San Diego, California 92093-0109, adamaron@ucsd.edu.
Damian M HerzMedical Research Council Brain Network Dynamics Unit, and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 3TH, United Kingdom.
Peter BrownMedical Research Council Brain Network Dynamics Unit, and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 3TH, United Kingdom.ORCID 0000-0002-5201-3044
Birte U ForstmannAmsterdam Brain and Cognition Center, University of Amsterdam, Psychology, Roetersstraat 15, Amsterdam 1018, The Netherlands, and.
Kareem ZaghloulNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Baltimore, Maryland 20892.

Funding

Investigating the neural mechanisms of human cognitive function through intracranial recordingsZIANS003144 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ZAGHLOUL, KAREEM · 2014 to 2025
$36.1M
How inhibitory control prevents thought intrusions and sensory and motor provocationsR01DA026452 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARON, ADAM ROBERT · 2009 to 2021
$4.0M
Medical Research Council G0901503Medical Research Council MC_UU_12024/1NIDA NIH HHS R01 DA026452
6 · The paper itself

Abstract

The subthalamic nucleus (STN) of the basal ganglia appears to have a potent role in action and cognition. Anatomical and imaging studies show that different frontal cortical areas directly project to the STN via so-called hyperdirect pathways. This review reports some of the latest findings about such circuits, including simultaneous recordings from cortex and the STN in humans, single-unit recordings in humans, high-resolution fMRI, and neurocomputational modeling. We argue that a major function of the STN is to broadly pause behavior and cognition when stop signals, conflict signals, or surprise signals occur, and that the fronto-STN circuits for doing this, at least for stopping and conflict, are dissociable anatomically and in terms of their spectral reactivity. We also highlight recent evidence for synchronization of oscillations between prefrontal cortex and the STN, which may provide a preferential "window in time" for single neuron communication via long-range connections.

Indexed as

Conflict, PsychologicalAnimalsChoice BehaviorCognitionComputer SimulationCortical SynchronizationFrontal LobeHumansModels, NeurologicalNerve NetNeural PathwaysReaction TimeSubthalamic Nucleusbasal gangliaconflictoscillationsresponse inhibitionstoppingsurprise

Identifiers

PMID27911752
PMCPMC5125216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.