ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Homeostasis Meets Motivation in the Battle to Control Food Intake.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 213 citations in OpenAlex.
- Liraglutide restores impaired associative learning in individuals with obesity.Nature metabolism · 2023Trial
- The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity.Metabolism: clinical and experimental · 2021Trial
- Trial
- Acute assessment of subjective appetite and implicated hormones after a hypnosis-induced hallucinated meal: a randomized cross-over pilot trial.Reviews in endocrine & metabolic disorders · 2020Trial
- Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity.The Journal of clinical investigation · 2020Trial
- Dorsomedial striatal GABA dynamics organize palatable reward consumption and are reshaped by GLP-1 receptor agonism.bioRxiv : the preprint server for biology · 2026Article
- Adolescent obesity induces sex-specific alterations of action control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Obesity is associated with greater variability of reward signals in the nucleus accumbens.Translational psychiatry · 2026Article
- Acute anti-obesity treatment with celastrol reduces body weight, cerebral inflammation and metabolic imbalances in mice.Molecular medicine (Cambridge, Mass.) · 2026Article
- A Preoptic Neuronal Population Regulates Energy Expenditure and Balance.bioRxiv : the preprint server for biology · 2026Article
- Impact of Cesarean Delivery on Reward Behavior and Tyrosine Hydroxylase in the Nucleus Accumbens of Adult Prairie Vole Offspring.Developmental psychobiology · 2026Article
- High-fat diet disrupts a septal control on feeding to promote obesity in male mice.Nature communications · 2025Article
- Advancements and challenges in the management of obesity using pharmacotherapy (Review).Experimental and therapeutic medicine · 2025Review
- The influence of high-fat diet on nicotine vapor self-administration, neuronal excitability, and leptin levels in adult mice.Physiology & behavior · 2025Article
- Binge Eating and Obesity Differentially Alter the Mesolimbic Endocannabinoid System in Rats.International journal of molecular sciences · 2025Article
- From attributes to value: Neural correlates of a front-of-package label on food decision-making - An fMRI study.PloS one · 2025Article
- Differential potentiation of odor aversion and yawning by melanocortin 4 receptor signaling in distinct regions of the ventral striatum.Frontiers in neuroscience · 2025Article
- Homeostatic-related peptides injected into the rat nucleus accumbens alter palatable eating and impact the binge-like intake of a sweetened fat diet during simultaneous μ-opioid receptor stimulation.Frontiers in neuroscience · 2025Article
- Function of orexin-1 receptor signaling in the olfactory tubercle in odor-guided attraction and aversion.Communications biology · 2024Article
- Distinct basal forebrain-originated neural circuits promote homoeostatic feeding and suppress hedonic feeding in male mice.Nature metabolism · 2024Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 3 countries.
Funding
Abstract
Signals of energy homeostasis interact closely with neural circuits of motivation to control food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior seen in eating disorders or obesity may arise from dysregulation of these interactions. Focusing on key brain regions involved in the control of food intake (ventral tegmental area, striatum, hypothalamus, and thalamus), we describe how activity of specific cell types embedded within these regions can influence distinct components of motivated feeding behavior. We review how signals of energy homeostasis interact with these regions to influence motivated behavioral output and present evidence that experience-dependent neural adaptations in key feeding circuits may represent cellular correlates of impaired food intake control. Future research into mechanisms that restore the balance of control between signals of homeostasis and motivated feeding behavior may inspire new treatment options for eating disorders and obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.