ArticleJournal of Alzheimer's disease : JAD2017
Comparison of Model-Based Indices of Cerebral Autoregulation and Vasomotor Reactivity Using Transcranial Doppler versus Near-Infrared Spectroscopy in Patients with Amnestic Mild Cognitive Impairment.
Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic potential of near-infrared spectroscopy in mild cognitive impairment and neurodegenerative disorders: Implications for resource-limited settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Functional near-infrared spectroscopy for identifying mild cognitive impairment and Alzheimer's disease: a systematic review.Frontiers in neurology · 2025Pooled it
- PRBS Gas Challenges Reveal Impaired Chemoreflex and Cholinergic Dynamics in MCI.Annals of biomedical engineering · 2026Article
- Correlation of prefrontal-based resting state functional connectivity with the degree of cognitive impairment in Alzheimer's disease: a functional near-infrared spectroscopy study.Behavioral and brain functions : BBF · 2025Article
- APOE4 carriers display loss of anticipatory cerebrovascular regulation across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Quantifying ventilatory control with 3% CO2 inhalation during exercise.Frontiers in physiology · 2025Article
- Data-based modeling of cerebral hemodynamics quantifies impairment of cerebral blood flow regulation in type-2 diabetes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet).Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- COJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Cognitive activity significantly affects the dynamic cerebral autoregulation, but not the dynamic vasoreactivity, in healthy adults.Frontiers in physiology · 2024Article
- Screening for Alzheimer's disease using prefrontal resting-state functional near-infrared spectroscopy.Frontiers in human neuroscience · 2022Article
- Dynamic effects of cholinergic blockade upon cerebral blood flow autoregulation in healthy adults.Frontiers in physiology · 2022Article
- A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.Journal of the American Geriatrics Society · 2021Article
- The Utility of Cerebrovascular Reactivity MRI in Brain Rehabilitation: A Mechanistic Perspective.Frontiers in physiology · 2021Review
- The Dynamic Relationship Between Cortical Oxygenation and End-TidalFrontiers in physiology · 2021Article
- A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases-Actual Applications and Future Perspectives.Diagnostics (Basel, Switzerland) · 2020Review
- Prognosis and risk factors for reocclusion after mechanical thrombectomy.Annals of clinical and translational neurology · 2020Article
- Quantification of dynamic cerebral autoregulation and COJournal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Detection of Mild Cognitive Impairment Using Convolutional Neural Network: Temporal-Feature Maps of Functional Near-Infrared Spectroscopy.Frontiers in aging neuroscience · 2020Article
- Dysregulation of CO2-Driven Heart-Rate Chemoreflex Is Related Closely to Impaired CO2 Dynamic Vasomotor Reactivity in Mild Cognitive Impairment Patients.Journal of Alzheimer's disease : JAD · 2020Article
Corrections and comments
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4 authors.
Funding
Abstract
We recently introduced model-based "physiomarkers" of dynamic cerebral autoregulation and CO2 vasomotor reactivity as an aid for diagnosis of early-stage Alzheimer's disease (AD) [1], where significant impairment of dynamic vasomotor reactivity (DVR) was observed in early-stage AD patients relative to age-matched controls. Milder impairment of DVR was shown in patients with amnestic mild cognitive impairment (MCI) using the same approach in a subsequent study [2]. The advocated approach utilizes subject-specific data-based models of cerebral hemodynamics to quantify the dynamic effects of resting-state changes in arterial blood pressure and end-tidal CO2 (the putative inputs) upon cerebral blood flow velocity (the putative output) measured at the middle cerebral artery via transcranial Doppler (TCD). The obtained input-output models are then used to compute model-based indices of DCA and DVR from model-predicted responses to an input pressure pulse or an input CO2 pulse, respectively. In this paper, we compare these model-based indices of DVR and DCA in 46 amnestic MCI patients, relative to 20 age-matched controls, using TCD measurements with their counterparts using Near-Infrared Spectroscopy (NIRS) measurements of blood oxygenation at the lateral prefrontal cortex in 43 patients and 22 age-matched controls. The goal of the study is to assess whether NIRS measurements can be used instead of TCD measurements to obtain model-based physiomarkers with comparable diagnostic utility. The results corroborate this view in terms of the ability of either output to yield model-based physiomarkers that can differentiate the group of aMCI patients from age-matched healthy controls.
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