Evidence map›Paper›PMID 27911187›Full record

ReviewRNA biology2017

FXR1a-associated microRNP: A driver of specialized non-canonical translation in quiescent conditions.

Syed I A Bukhari, Shobha Vasudevan

Abstract readReview
In one paragraph

Review in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Circadian Control of Protein Synthesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Syed I A Bukharia Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA.
Shobha Vasudevana Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA.

Funding

(PQC6) Molecular Determinants of Quiescent Cancer CellsR01CA185086 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VASUDEVAN, SHOBHA · 2014 to 2017
$1.8M
Post-transcriptional Gene Expression of the TNF alpha by an FXR1a-associated microRNPR01GM100202 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI VASUDEVAN, SHOBHA · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA185086NIGMS NIH HHS R01 GM100202
6 · The paper itself

Abstract

Eukaryotic protein synthesis is a multifaceted process that requires coordination of a set of translation factors in a particular cellular state. During normal growth and proliferation, cells generally make their proteome via conventional translation that utilizes canonical translation factors. When faced with environmental stress such as growth factor deprivation, or in response to biological cues such as developmental signals, cells can reduce canonical translation. In this situation, cells adapt alternative modes of translation to make specific proteins necessary for required biological functions under these distinct conditions. To date, a number of alternative translation mechanisms have been reported, which include non-canonical, cap dependent translation and cap independent translation such as IRES mediated translation. Here, we discuss one of the alternative modes of translation mediated by a specialized microRNA complex, FXR1a-microRNP that promotes non-canonical, cap dependent translation in quiescent conditions, where canonical translation is reduced due to low mTOR activity.

Indexed as

AnimalsArgonaute ProteinsEukaryotic Initiation Factor-4GExoribonucleasesFragile X Messenger Ribonucleoprotein 1Gene Expression RegulationHumansMicroRNAsPoly AProtein BindingProtein BiosynthesisRNA Cap-Binding ProteinsRNA CapsRNA, MessengerTOR Serine-Threonine KinasesArgonaute ProteinsEukaryotic Initiation Factor-4GExoribonucleasesFragile X Messenger Ribonucleoprotein 1MicroRNAsPoly ARNA Cap-Binding ProteinsRNA CapsRNA, MessengerTOR Serine-Threonine Kinases4EBP dephosphorylationDAP5FXR1alow mTOR activitymicroRNAmRNA cap bindingnon-canonical translationPARNpoly(A) shorteningquiescence

Identifiers

PMID27911187
PMCPMC5324761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.