ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2017
Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Coexistence of thyroid sclerosing mucoepidermoid carcinoma with eosinophilia and mucosa-associated lymphoid tissue lymphoma in Hashimoto thyroiditis: a case report.Journal of rural medicine : JRM · 2026Article
- Sclerosing mucoepidermoid carcinoma of salivary glands.Virchows Archiv : an international journal of pathology · 2025Article
- Sclerosing mucoepidermoid carcinoma of the thyroid with eosinophilia: a case report and review of the literature.Journal of medical case reports · 2025Review
- Histopathology of C Cells and Medullary Thyroid Carcinoma.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025Review
- Case Report: Mucoepidermoid carcinoma in rare locations: a report of two cases.Frontiers in oncology · 2025Article
- Aggressive Primary Thyroid Mucoepidermoid Carcinoma with Extensive Pulmonary Involvement.Biomedicines · 2024Article
- Detection of CSF1 gene derangement in 'sclerosing mucoepidermoid carcinoma with eosinophilia' of the parotid gland masquerading as Langerhans cell histiocytosis.Clinical case reports · 2023Article
- Primary Thyroid Mucoepidermoid Carcinoma (MEC) Is Clinically, Prognostically, and Molecularly Different from Sclerosing MEC with Eosinophilia: A Multicenter and Integrated Study.Endocrine pathology · 2023Article
- Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid and Mucoepidermoid Carcinoma of the Thyroid: What's in a Name?Endocrine pathology · 2023Article
- Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.Endocrinology and metabolism (Seoul, Korea) · 2022Review
- Squamous Differentiation in the Thyroid: Metaplasia, Neoplasia, or Bystander?International journal of surgical pathology · 2022Article
- Overview of the 2022 WHO Classification of Thyroid Neoplasms.Endocrine pathology · 2022Review
- NSD3-NUTM1-rearranged carcinoma of the median neck/thyroid bed developing after recent thyroidectomy for sclerosing mucoepidermoid carcinoma with eosinophilia: report of an extraordinary case.Virchows Archiv : an international journal of pathology · 2021Article
- Sclerosing mucoepidermoid carcinoma of the salivary glands: report of three cases with special concern to the counterpart accompanied by eosinophilia.Medical molecular morphology · 2021Article
- Perithyroidal Salivary Gland Acinic Cell Carcinoma: Morphological and Molecular Attributes of a Unique Lesion.Head and neck pathology · 2021Article
- High-grade mucoepidermoid carcinoma in the thyroid gland with poor prognosis.Yeungnam University journal of medicine · 2021Article
- Salivary-Like Tumors of the Thyroid: A Comprehensive Review of Three Rare Carcinomas.Head and neck pathology · 2021Review
- Anaplastic thyroid carcinoma combined with sclerosing mucoepidermoid carcinoma with eosinophilia: A case report.Medicine · 2020Article
- Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers.Endocrine pathology · 2020Review
- Activating BRAF mutation in sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: two case reports and review of the literature.Journal of medical case reports · 2019Review
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Sclerosing mucoepidermoid carcinoma with eosinophilia is a rare thyroid neoplasm of uncertain pathogenesis that resembles salivary gland mucoepidermoid carcinoma. This multi-institutional study characterizes the clinicopathologic and molecular features of this tumor by utilizing next-generation sequencing to assess common mutations and gene fusions involved in thyroid carcinogenesis as well as fluorescence in-situ hybridization for MAML2 translocations typical of salivary gland mucoepidermoid carcinoma. Nine cases (6 females and 3 males, mean age: 59 years, range 30-77 years) were identified. All cases were comprised of nests and strands of tumor cells with both squamous and mucinous differentiation embedded in a fibrohyaline stroma with an inflammatory infiltrate replete with eosinophils. All cases were p63 positive, thyroglobulin negative and showed variable expression of TTF-1. All nine cases were negative for MAML2 rearrangements. Five cases successfully tested by next-generation sequencing (ThyroSeq v.2 assay) were negative for mutations and translocations commonly involved in thyroid carcinogenesis. NTRK1 showed overexpression but no evidence of translocation. On follow-up, one patient died of persistent disease, whereas one of four remaining patients with available follow-up (mean: 7.3 years, range 4-11 years) demonstrated recurrence at 4 years. Thus, we show that sclerosing mucoepidermoid carcinoma with eosinophilia appears molecularly and morphologically distinct from follicular and C-cell-derived thyroid tumors as well as from salivary gland mucoepidermoid carcinoma. The overall and recurrence-free survival for these patients may be lower than for other well-differentiated thyroid cancers.
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