ArticleScientific reports2016
Real-time PCR-based serotyping of Streptococcus agalactiae.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Molecular assays for the diagnosis of sepsis in neonates: a diagnostic test accuracy review.The Cochrane database of systematic reviews · 2025Pooled it
- Structure-Informed Prioritization of Phytochemical Antistreptococcal Candidates: Integrated Molecular Docking and In Vitro Proof-of-Concept Validation AgainstCurrent issues in molecular biology · 2026Article
- Virulence and pathogenicity of group BVirulence · 2025Review
- Genomic characterization of group BMicrobial genomics · 2025Article
- Maternal and neonatal outcomes of Group B Streptococcus colonization: a retrospective study.BMC infectious diseases · 2025Article
- Streamlined boiling lysis DNA extraction for Gram-positive aquaculture pathogen Streptococcus agalactiae.Archives of microbiology · 2024Article
- Performance Evaluation of NovaplexMicroorganisms · 2024Article
- Strain-level genomic analysis of serotype, genotype and virulence gene composition of group B streptococcus.Frontiers in cellular and infection microbiology · 2024Article
- Human Fecal Carriage of Streptococcus agalactiae Sequence Type 283, Thailand.Emerging infectious diseases · 2023Article
- Group B streptococcus virulence factors associated with different clinical syndromes: Asymptomatic carriage in pregnant women and early-onset disease in the newborn.Frontiers in microbiology · 2023Article
- Rectovaginal Colonization with Serotypes of Group BPathogens (Basel, Switzerland) · 2022Article
- Prevalence of group B streptococcus colonization in pregnant women in Jiangsu, East China.BMC infectious diseases · 2021Article
- Development of a droplet digital PCR method for detection of Streptococcus agalactiae.BMC microbiology · 2020Article
- Development and analytical validation of real-time PCR for the detection of Streptococcus agalactiae in pregnant women.BMC pregnancy and childbirth · 2020Article
- Molecular characterization of Streptococcus agalactiae isolated from pregnant women and newborns at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.BMC infectious diseases · 2020Article
- Article
- The effect of group B streptococcus on maternal and infants' prognosis in Guizhou, China.Bioscience reports · 2019Article
- High Rate of Serotype VThe American journal of tropical medicine and hygiene · 2019Article
- Article
- Improving the Sensitivity of Real-time PCR Detection of Group B Streptococcus Using Consensus Sequence-Derived Oligonucleotides.Open forum infectious diseases · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group B Streptococcus (GBS) is an encapsulated, gram-positive pathogen that is an important cause of neonatal invasive infections, including sepsis and meningitis. There are ten known GBS serotypes based on distinct capsule compositions (Ia, Ib, II-IX), and current candidate capsular polysaccharide conjugate vaccines target only a subset of these. Serotyping of GBS isolates is important for understanding local epidemiology and for monitoring for serotype replacement or capsular switching. However, serotyping generally requires either latex agglutination, multiplex PCR with analysis of band sizes, or analysis of whole genome sequences-all techniques that are either expensive or not widely available. Here we report the development of a robust real-time PCR assay for determining GBS serotypes. Using both a diverse reference set of strains encompassing all ten serotypes and a collection of clinical isolates, we demonstrate concordance between real-time PCR serotyping and latex agglutination. We propose that real-time PCR serotyping represents an attractive alternative to current serotyping methods and may allow for improved acquisition of GBS serotype data.
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