ArticleAsian Pacific journal of cancer prevention : APJCP2016
Risk Factors for Endometrial Cancer: Results from a Hospital-Based Case-Control Study
Article in Asian Pacific journal of cancer prevention : APJCP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
- Pubertal timing and incident uterine cancer in the Sister Study cohort.International journal of cancer · 2026Article
- Article
- SAMD4B: a novel prognostic biomarker of endometrial carcinoma.Translational cancer research · 2025Article
- Fertility-sparing treatment for overweight patients with early-stage endometrial cancer or atypical endometrial hyperplasia under weight loss intervention.Journal of cancer research and clinical oncology · 2025Article
- Current Unveiling Key Research Trends in Endometrial Cancer: A Comprehensive Topic Modeling Analysis.Healthcare (Basel, Switzerland) · 2025Article
- Endometrial cancer and associated risk factors among non-pregnant women with abnormal uterine bleeding in Kampala, Uganda: a 7-year experience from a Single Institution.African health sciences · 2025Article
- From Abnormal Uterine Bleeding to Malignancy: The Role of Hormonal Profiling and Histopathology in Early Detection of Endometrial Carcinoma.Advanced biomedical research · 2025Article
- Endometrial Cancer in Reproductive-Aged Females: Etiology and Pathogenesis.Biomedicines · 2024Review
- Estradiol and Estrone Have Different Biological Functions to Induce NF-κB-Driven Inflammation, EMT and Stemness in ER+ Cancer Cells.International journal of molecular sciences · 2023Article
- Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome.International journal of environmental research and public health · 2022Article
- Article
- Models including preoperative plasma levels of angiogenic factors, leptin and IL-8 as potential biomarkers of endometrial cancer.Frontiers in oncology · 2022Article
- Rate of Significant Endometrial Pathology in Women at Low Risk for Endometrial Hyperplasia or Cancer Presenting with Abnormal Uterine Bleeding.Pragmatic and observational research · 2020Article
- Genetics of IL6 polymorphisms: Case-control study of the risk of endometrial cancer.Molecular genetics & genomic medicine · 2019Article
- Increased Incidence of Endometrial Cancer Following the Women's Health Initiative: An Assessment of Risk Factors.Journal of women's health (2002) · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The purpose of this investigation was to examine the association between endometrial cancer and possible etiological agents. Methods: A case-control study was conducted in Iran between March 2012 and May 2016. The demographic and reproductive factors of 205 women with endometrial cancer were compared, and 590 healthy cases were participated in the control group. For each endometrial cancer case, there were three controls, who were matched in terms of age and residence. The data were considered significant at p ≤0.05. Results: After adjusting the variables, the nulliparity (OR 6.23, 95% CI 2.86-13.59), the nulligravidity (OR 5.94, 95% CI 2.51-14.06), the positive family history of reproductive cancer (OR 4.97, 95% CI 2.33-10.59), the infertility history (OR 2.38, 95%CI 1.32-4.31), the obesity (BMI ≥25) (OR 1.71, 95% CI 1.16-2.52), the early menarche age (<12 years) (OR 2.10, 95% CI 1.17-3.75), and the hormonal contraception use (OR 1.69, 95% CI 1.15-2.49) were found to be associated with an increased risk of endometrial cancer. Nevertheless, the education level, the job of women, the marital age, the leisure activities, and the breast feeding were not found to be associated with the endometrial cancer after adjusting the variables. Conclusion: Scheduling of the screening program is vitally indispensable to identify endometrial cancer in women with nulliparity, nulligravidity and the positive family history of cancer. In addition, women with early menarche, those with the history of infertility, the obese ones, and those who use contraception pills need to be particularly aware of the potential risks.
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