ArticleNature communications2016
The genetic basis and fitness consequences of sperm midpiece size in deer mice.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- An X-to-autosome-to-Y chromosome amplified retrogene family functions in spermatids.Current biology : CB · 2026Article
- D-Mannose-Mediated metabolic pathways sustain the molecular signatures of sperm function and fertilization.Journal of advanced research · 2025Article
- Mating system variation and gene expression in the male reproductive tract of Peromyscus mice.Molecular ecology · 2025Article
- The rapidly evolving X-linkedeLife · 2024Article
- The Rapidly Evolving X-linkedbioRxiv : the preprint server for biology · 2024Article
- The evolution of centriole degradation in mouse sperm.Nature communications · 2024Article
- Differences in sperm morphology between Alouatta palliata and Alouatta pigra are consistent with the intensity of sperm competition in each species.American journal of primatology · 2023Article
- Evolution in reproductive tempo and investment across the Peromyscus radiation.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Review
- An enhancer ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The impact of diet quality on the velocity, morphology and normality of sperm in the zebra finch Taeniopygia guttata.The Journal of experimental biology · 2022Article
- Mitochondria-cytoskeleton interactions in mammalian sperm revealed by cryoelectron tomography.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- In-cell structures of conserved supramolecular protein arrays at the mitochondria-cytoskeleton interface in mammalian sperm.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- A sex chromosome inversion is associated with copy number variation of mitochondrial DNA in zebra finch sperm.Royal Society open science · 2021Article
- Review
- Article
- Characterization of Bottlenose DolphinBiology · 2021Article
- Relationship between the Length of Sperm Tail Mitochondrial Sheath and Fertility Traits in Boars Used for Artificial Insemination.Antioxidants (Basel, Switzerland) · 2020Article
- Differential Expression in Testis and Liver Transcriptomes from Four Species of Peromyscus (Rodentia: Cricetidae).Genome biology and evolution · 2020Article
- Sperm morphology and count vary with fine-scale changes in local density in a wild lizard population.Oecologia · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
An extensive array of reproductive traits varies among species, yet the genetic mechanisms that enable divergence, often over short evolutionary timescales, remain elusive. Here we examine two sister-species of Peromyscus mice with divergent mating systems. We find that the promiscuous species produces sperm with longer midpiece than the monogamous species, and midpiece size correlates positively with competitive ability and swimming performance. Using forward genetics, we identify a gene associated with midpiece length: Prkar1a, which encodes the R1α regulatory subunit of PKA. R1α localizes to midpiece in Peromyscus and is differentially expressed in mature sperm of the two species yet is similarly abundant in the testis. We also show that genetic variation at this locus accurately predicts male reproductive success. Our findings suggest that rapid evolution of reproductive traits can occur through cell type-specific changes to ubiquitously expressed genes and have an important effect on fitness.
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