Evidence map›Paper›PMID 27910738›Full record

ReviewActa orthopaedica2016

Cartilage repair in the degenerative ageing knee.

Mats Brittberg, Andreas H Gomoll, José A Canseco, Jack Far, Martin Lind, James Hui

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta orthopaedica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  10. Collagen-Based Scaffolds for Meniscal Repair and Regeneration.Journal of tissue engineering and regenerative medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

Mats Brittberga Cartilage Research Unit , University of Gothenburg, Region Halland Orthopaedics, Kungsbacka Hospital , Kungsbacka , Sweden.
Andreas H Gomollb Harvard Medical School, Cartilage Repair Center, Brigham and Women's Hospital , Boston , MA.
José A Cansecoc Department of Orthopaedic Surgery , University of Pennsylvania , Philadelphia , PA.
Jack Fard Indiana University School of Medicine, OrthoIndy Cartilage Restoration Center , Indianapolis , IN , USA.
Martin Linde Division of Sports Traumatology, Department of Orthopedics , Aarhus University Hospital , Århus , Denmark.
James Huif Department of Orthopaedic Surgery , Yong Loo Lin School of Medicine, National University Singapore , Singapore.
Aarhus University Hospital · DKBrigham and Women's Hospital · USHallands sjukhus Kungsbacka · SEIndiana University – Purdue University Indianapolis · USNational University of Singapore · SGUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose - Cartilage damage can develop due to trauma, resulting in focal chondral or osteochondral defects, or as more diffuse loss of cartilage in a generalized organ disease such as osteoarthritis. A loss of cartilage function and quality is also seen with increasing age. There is a spectrum of diseases ranging from focal cartilage defects with healthy surrounding cartilage to focal lesions in degenerative cartilage, to multiple and diffuse lesions in osteoarthritic cartilage. At the recent Aarhus Regenerative Orthopaedics Symposium (AROS) 2015, regenerative challenges in an ageing population were discussed by clinicians and basic scientists. A group of clinicians was given the task of discussing the role of tissue engineering in the treatment of degenerative cartilage lesions in ageing patients. We present the outcomes of our discussions on current treatment options for such lesions, with particular emphasis on different biological repair techniques and their supporting level of evidence. Results and interpretation - Based on the studies on treatment of degenerative lesions and early OA, there is low-level evidence to suggest that cartilage repair is a possible treatment for such lesions, but there are conflicting results regarding the effect of advanced age on the outcome. We concluded that further improvements are needed for direct repair of focal, purely traumatic defects before we can routinely use such repair techniques for the more challenging degenerative lesions. Furthermore, we need to identify trigger mechanisms that start generalized loss of cartilage matrix, and induce subchondral bone changes and concomitant synovial pathology, to maximize our treatment methods for biological repair in degenerative ageing joints.

Indexed as

AgingCartilage, ArticularChondrocytesHumansKnee InjuriesKnee JointMesenchymal Stem Cell TransplantationOsteoarthritis, KneeRegenerative MedicineTissue EngineeringTissue Scaffolds

Identifiers

PMID27910738
PMCPMC5389429
OpenAlexW2558687247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.