Evidence map›Paper›PMID 27909897›Full record

ArticleJournal of physiology and biochemistry2017

NHA2 is expressed in distal nephron and regulated by dietary sodium.

Kalyan C Kondapalli, R Todd Alexander, Jennifer L Pluznick, Rajini Rao

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of physiology and biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trafficking of the human NaProtein science : a publication of the Protein Society · 2026
    Article
  2. Structure and Inhibition of the Human NaInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. NaInternational journal of molecular sciences · 2023
    Review
  5. Allosteric links between the hydrophilic N-terminus and transmembrane core of human NaProtein science : a publication of the Protein Society · 2022
    Article
  6. Prokaryotic NaInternational journal of molecular sciences · 2022
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kalyan C KondapalliDepartment of Physiology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205, USA.
R Todd AlexanderDivision of Nephrology, Department of Pediatrics, University of Alberta, 11405-87 Avenue, Edmonton, AB, T6G 1C9, Canada.
Jennifer L PluznickDepartment of Physiology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205, USA.
Rajini RaoDepartment of Physiology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205, USA. rrao@jhmi.edu.ORCID http://orcid.org/0000-0002-1833-5971
Johns Hopkins University · USUniversity of Alberta · CA

Funding

Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2011 to 2020
$12.0M
Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Transport Mechanism and Renal Function of a Newly Recognized Na+/H+ ExchangerR01DK108304 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2015 to 2019
$2.3M
Olfactory Proteins in the Kidney and Regulation of Glomerular Filtration RateR00DK081610 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI PLUZNICK, JENNIFER L · 2010 to 2012
$760k
Olfactory Proteins in the Kidney and Regulation of Glomerular Filtration RateK99DK081610 · NIDDK · YALE UNIVERSITY · PI PLUZNICK, JENNIFER L · 2008 to 2010
$206k
NIDDK NIH HHS K99 DK081610NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R00 DK081610NIDDK NIH HHS R01 DK108304NIGMS NIH HHS T32 GM008752
6 · The paper itself

Abstract

Increased renal reabsorption of sodium is a significant risk factor in hypertension. An established clinical marker for essential hypertension is elevated sodium lithium countertransport (SLC) activity. NHA2 is a newly identified Na

Indexed as

Gene Expression RegulationAnimalsAntiportersAquaporin 2BiomarkersCell PolarityHypertensionKidney Tubules, CollectingKidney Tubules, DistalMaleMice, Inbred C57BLMice, Inbred StrainsNephronsOrgan SpecificityProtein TransportRNA, MessengerAntiportersAqp2 protein, mouseAquaporin 2BiomarkersNHA2 protein, mouseRNA, MessengerSodium Chloride, DietarySodium Chloride SymportersSodium, DietaryVacuolar Proton-Translocating ATPasesHypertensionNa+/H+ antiportNephronNHEDC2SLCSodium diet

Identifiers

PMID27909897
PMCPMC5545883
OpenAlexW2558252046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.