Trial reportClinical oral investigations2017
Antimicrobial photodynamic therapy vs. local minocycline in addition to non-surgical therapy of deep periodontal pockets: a controlled randomized clinical trial.
Trial report in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- The Effect of Non-Surgical Periodontal Therapy on Subgingival Microbiota: A Systematic Review and Meta-Analysis.Journal of periodontal research · 2025Pooled it
- The long-term efficacy of tetracycline class antimicrobials as local adjuncts in the treatment of chronic periodontitis: a systematic review and meta-analysis.Frontiers in dental medicine · 2025Pooled it
- Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases.The Cochrane database of systematic reviews · 2024Pooled it
- Efficacy of antimicrobial photodynamic therapy (aPDT) for nonsurgical treatment of periodontal disease: a systematic review.Lasers in medical science · 2021Pooled it
- Indocyanine green doped with chitosan nanoparticles based antimicrobial photodynamic therapy in periodontitis patients: A randomized clinical trial.World journal of experimental medicine · 2026Trial
- Impact of Molar Furcations on Photodynamic Therapy Outcomes: A 6-Month Split-Mouth Randomized Clinical Trial.International journal of environmental research and public health · 2020Trial
- Supramolecular strategy for compartment pathogen clearance and immuno-metabolic homeostasis to treat periodontitis.Nature communications · 2026Article
- Microbiological Impact of Antimicrobial Photodynamic Therapy in Non-Surgical Periodontal Treatment.Pharmaceutics · 2025Review
- Preclinical Studies on the Safety and Toxicity of Photoditazine in the Antibacterial Photodynamic Therapy of Uropathogenic Bacteria.Biomedicines · 2023Article
- Natural polyphenol self-assembled pH-responsive nanoparticles loaded into reversible hydrogel to inhibit oral bacterial activity.Molecular biomedicine · 2022Article
- One-Year Clinical, Microbiological and Immunological Results of Local Doxycycline or Antimicrobial Photodynamic Therapy for Recurrent/Persisting Periodontal Pockets: A Randomized Clinical Trial.Antibiotics (Basel, Switzerland) · 2022Article
- Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study.Diagnostics (Basel, Switzerland) · 2022Article
- Clinical applications of antimicrobial photodynamic therapy in dentistry.Frontiers in microbiology · 2022Review
- Classic vs. Novel Antibacterial Approaches for Eradicating Dental Biofilm as Adjunct to Periodontal Debridement: An Evidence-Based Overview.Antibiotics (Basel, Switzerland) · 2021Review
- Clindamycin as an Alternative Option in Optimizing Periodontal Therapy.Antibiotics (Basel, Switzerland) · 2021Review
- Inhibitory Effect ofMedicina (Kaunas, Lithuania) · 2021Article
- Effectiveness of Antimicrobial Photodynamic Therapy in the Treatment of Periodontitis: A Systematic Review and Meta-Analysis of In Vivo Human Randomized Controlled Clinical Trials.Pharmaceutics · 2021Review
- Clinical and Microbiological Evaluation of Local Doxycycline and Antimicrobial Photodynamic Therapy during Supportive Periodontal Therapy: A Randomized Clinical Trial.Antibiotics (Basel, Switzerland) · 2021Article
- Professionally Delivered Local Antimicrobials in the Treatment of Patients with Periodontitis-A Narrative Review.Dentistry journal · 2020Review
- Laser-Assisted aPDT Protocols in Randomized Controlled Clinical Trials in Dentistry: A Systematic Review.Dentistry journal · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the additional influence of either antimicrobial photodynamic therapy (aPDT; Helbo® Photodynamic Systems) or local application of minocycline microspheres (MC; Arestin, OraPharma) on clinical and microbiological healing results in deep periodontal pockets (PPD ≥6 mm) following non-surgical periodontal therapy (SRP). MATERIALS AND
methodsForty-five patients with chronic periodontitis were evaluated: test group aPDT + SRP (n = 15), positive control group MC + SRP (n = 15), and negative control group SRP-alone (n = 15). Clinical and microbiological healing parameters were recorded in every patient for four experimental teeth at baseline, 6 weeks, and 3, 6, and 12 months. Wilcoxon signed-rank test and Mann-Whitney U test were used for statistical analysis (α = 0.05).
resultsSignificant improvements in clinical and microbiological parameters were found for all groups after 6 weeks and 3, 6, and 12 months. Differences between groups were not statistically significant. Changes after 12 months [median (25/75%)] are as follows: reduction in PPD [mm]: aPDT + SRP 2 (1/3), MC + SRP 3 (1/4), SRP-alone 2 (1/3); percentage of residual BOP positive teeth [%]: aPDT + SRP 75 (25/100), MC + SRP 33.3 (0/50), SRP-alone 66.7 (25/75).
conclusionsWithin the limitations of this study, neither the applied aPDT system nor MC showed a significant additional influence on clinical and microbiological healing outcomes in deep periodontal pockets compared to SRP alone. CLINICAL RELEVANCE: In deep periodontal defects, the efficacy of non-surgical periodontal treatment seems not to be improved by adjunctive use of antimicrobial photodynamic therapy or minocycline microspheres.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.