Evidence map›Paper›PMID 27909842›Full record

ArticleJournal of computational neuroscience2017

The relationship between nernst equilibrium variability and the multifractality of interspike intervals in the hippocampus.

Stephen R Meier, Jarrett L Lancaster, Dustin Fetterhoff, Robert A Kraft, Robert E Hampson, Joseph M Starobin

Abstract read
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In one paragraph

Article in Journal of computational neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephen R MeierDepartment of Applied Mathematics and Statistics, State University of New York, Stony Brook, NY, 11794, USA. stephen.meier@stonybrook.edu.ORCID http://orcid.org/0000-0002-5263-7893
Jarrett L LancasterDepartment of Physics, Roanoke College, Salem, VA, 24153, USA.
Dustin FetterhoffDepartment of Biology II, Ludwig Maximilian University of Munich, Munich, Germany.
Robert A KraftDepartment of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA.
Robert E HampsonDepartment of Physiology & Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA.
Joseph M StarobinDepartment of Nanoscience, The University of North Carolina, Greensboro, NC, 27401, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatiotemporal patterns of action potentials are considered to be closely related to information processing in the brain. Auto-generating neurons contributing to these processing tasks are known to cause multifractal behavior in the inter-spike intervals of the output action potentials. In this paper we define a novel relationship between this multifractality and the adaptive Nernst equilibrium in hippocampal neurons. Using this relationship we are able to differentiate between various drugs at varying dosages. Conventional methods limit their ability to account for cellular charge depletion by not including these adaptive Nernst equilibria. Our results provide a new theoretical approach for measuring the effects which drugs have on single-cell dynamics.

Indexed as

Action PotentialsModels, NeurologicalElectronic Data ProcessingHippocampusNeuronsCannabidiolDale’s principleHurst exponentMultifractal detrended fluctuation analysisPoisson processPyramidal neuronsTetrahydrocannabinol

Identifiers

PMID27909842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.