Evidence map›Paper›PMID 27909828›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2017

The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection.

Anne Horn, C Scheller, S du Plessis, R Burger, G Arendt, J Joska, S Sopper, C M Maschke, M Obermann, I W Husstedt and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Childhood trauma and genetic variation in theIBRO neuroscience reports · 2022
    Article
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Anne HornInstitute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str. 7, 97078, Wuerzburg, Germany. anne.horn@uniklinik-freiburg.de.
C SchellerInstitute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str. 7, 97078, Wuerzburg, Germany.
S du PlessisDepartment of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
R BurgerDepartment of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany.
G ArendtDepartment of Neurology, University Hospital of Duesseldorf, Duesseldorf, Germany.
J JoskaDepartment of Psychiatry, University of Cape Town, Cape Town, South Africa.
S SopperIFTZ, Medical University Innsbruck, Innsbruck, Austria.
C M MaschkeDepartment of Neurology, University Hospital of Duisburg-Essen, Duisburg-Essen, Germany.
M ObermannDepartment of Neurology, University Hospital of Duisburg-Essen, Duisburg-Essen, Germany.
I W HusstedtDepartment of Neurology, University Hospital of Muenster, Muenster, Germany.
J HainInstitute of Mathematics and Informatics, Chair of Mathematics VIII (Statistics), University of Wuerzburg, Wuerzburg, Germany.
P RiedererCenter of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany.
E KoutsilieriInstitute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str. 7, 97078, Wuerzburg, Germany.
German Competence Network HIV/AIDS
University of Würzburg · DEInnsbruck Medical University · ATUniversity Hospital Münster · DEUniversity of Cape Town · ZAUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We showed previously that higher levels in CSF dopamine in HIV patients are associated with the presence of the dopamine transporter (DAT) 10/10-repeat allele which was also detected more frequently in HIV-infected individuals compared to uninfected subjects. In the current study, we investigated further whether other genetic dopamine (DA)-related polymorphisms may be related with changes in CSF DA levels and frequency of HIV infection in HIV-infected subjects. Specifically, we studied genetic polymorphisms of brain-derived neurotrophic factor, catechol-O-methyltransferase, and dopamine receptors DRD2, DRD3, and DRD4 genetic polymorphisms in uninfected and HIV-infected people in two different ethnical groups, a German cohort (Caucasian, 72 individuals with HIV infection and 22 individuals without HIV infection) and a South African cohort (Xhosan, 54 individuals with HIV infection and 19 individuals without HIV infection). We correlated the polymorphisms with CSF DA levels, HIV dementia score, CD4

Indexed as

AdultBiomarkersBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCD4 Lymphocyte CountCohort StudiesDopamineFemaleGene FrequencyGenotyping TechniquesGermanyHIV InfectionsHumansMaleMiddle AgedNeuropsychological TestsBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCOMT protein, humanDopamineReceptors, DopamineAfricaDATDopamineDopamine receptorsHIVInfectionPolymorphisms

Identifiers

PMID27909828
OpenAlexW2558028731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.