Trial reportJournal of neurology2017
Increasing the sensitivity of MRI for the detection of multiple sclerosis lesions by long axial coverage of the spinal cord: a prospective study in 119 patients.
Trial report in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Expert Panel Consensus Guidelines of the German Society of Neuroradiology on the Use of Magnetic Resonance Imaging in the Diagnosis and Monitoring of Multiple Sclerosis.Clinical neuroradiology · 2026Guideline
- Reliability and validity of adolescent idiopathic scoliosis diagnosis based on mobile phone AI scoliosis screening algorithm and infrared 3D spine assessment system.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Article
- Tips and tricks of spinal cord biopsy: insights from a multicenter series of 61 patients.Journal of neuro-oncology · 2025Article
- Utility of spinal cord axial-T2 sequence in a population-based cohort of multiple sclerosis.Journal of neurology · 2025Article
- Fractal-Based Architectures with Skip Connections and Attention Mechanism for Improved Segmentation of MS Lesions in Cervical Spinal Cord.Diagnostics (Basel, Switzerland) · 2025Article
- Neurodegeneration and Demyelination in the Multiple Sclerosis Spinal Cord: Clinical, Pathological, and 7T MRI Perspectives.Neurology · 2025Article
- Automatic segmentation of spinal cord lesions in MS: A robust tool for axial T2-weighted MRI scans.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Recent progress in epidemiology, clinical features, and therapy of multiple sclerosis in China.Therapeutic advances in neurological disorders · 2023Review
- Magnetic Resonance Imaging in Primary Progressive Multiple Sclerosis Patients : Review.Clinical neuroradiology · 2022Review
- Multiple sclerosis lesions and atrophy in the spinal cord: Distribution across vertebral levels and correlation with disability.NeuroImage. Clinical · 2022Article
- Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability.Brain : a journal of neurology · 2020Article
- Spinal Cord Involvement in MS and Other Demyelinating Diseases.Biomedicines · 2020Review
- Spatial distribution of multiple sclerosis lesions in the cervical spinal cord.Brain : a journal of neurology · 2019Article
- Advances in spinal cord imaging in multiple sclerosis.Therapeutic advances in neurological disorders · 2019Review
- The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnostic imaging criteria of multiple sclerosis (MS) include the spatial and temporal dissemination of cerebral and/or spinal cord lesions. Magnetic resonance imaging (MRI) is the method of choice for initial diagnosis and follow-up disease monitoring. Current guidelines for spinal MRI recommend sagittal imaging of the spinal cord and lesion confirmation on axial planes if lesions are detected. Sagittal imaging is, however, hampered by technical (e.g. partial volume effects, motion artifacts) and anatomical (e.g. scoliosis) limitations. We hypothesized that long coverage of the spinal cord by axial image acquisition has superior diagnostic performance compared to sagittal imaging and can identify otherwise undetected lesions. Our prospective clinical study included 119 MS patients. Axial MRI revealed ~2.5-fold more lesions than the sagittal angulation (axial lesion load: 4.0 ± 2.4 vs. 1.6 ± 1.2 lesions on sagittal planes, p < 0.001). Importantly, 20 patients (17%) with normal sagittal MRI scans had unequivocal lesions only visible on axial planes (mean lesion number on axial planes in these patients: 2.0 ± 1.3). Moreover, 45 patients (38%) showed a discrepancy of ≥3 lesions that were found additionally on axial scans (mean difference 4.4 ± 1.7). Additionally identified lesions were on average smaller in size and located more laterally within the spinal cord. No lesion on sagittal images was missed on the axial angulation. Our study demonstrates that imaging of small axial segments for lesion confirmation is insufficient in spinal imaging. We recommend implementing a long coverage axial MRI sequence for spinal imaging of MS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.