Evidence map›Paper›PMID 27909795›Full record

ReviewZeitschrift fur Rheumatologie2017

Altered gut microbiota in RA: implications for treatment.

Y Kang, Y Cai, X Zhang, X Kong, J Su

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Zeitschrift fur Rheumatologie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03033199 (A Multi-center Randomized Clinical Trial of Regulating Gut Microbiota by Probiotic Agents in Management of Immune Thrombocytopenia), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03033199 phase2unknown statusnot on this map

A Multi-center Randomized Clinical Trial of Regulating Gut Microbiota by Probiotic Agents in Management of Immune Thrombocytopenia

TypeinterventionalSponsorShandong UniversityRan2017 to 2018Enrolled60ConditionsImmune ThrombocytopeniaArmsProbiotic Agent, Dexamethasone
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Gut-joint axis: Gut dysbiosis can contribute to the onset of rheumatoid arthritisFrontiers in cellular and infection microbiology · 2023
    Review
  8. Lipid metabolism and rheumatoid arthritis.Frontiers in immunology · 2023
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Y KangMedical Faculty, Kunming University of Science and Technology, 650500, Kunming, Yunnan, China.
Y CaiMedical Faculty, Kunming University of Science and Technology, 650500, Kunming, Yunnan, China.
X ZhangMedical Faculty, Kunming University of Science and Technology, 650500, Kunming, Yunnan, China.
X KongMedical Faculty, Kunming University of Science and Technology, 650500, Kunming, Yunnan, China.
J SuMedical Faculty, Kunming University of Science and Technology, 650500, Kunming, Yunnan, China. Junhong_su@163.com.
Kunming University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease with progressive joint disorder. The complex interplay of genetic and environmental influences is important for the development of the disease. A growing body of evidence has shed light on the association of dysbiosis of gut microbiota with RA. Certain gut microbial strains have been shown to inhibit or attenuate immune responses in RA experimental models, suggesting that specific species among intestinal commensal bacteria may play either a pathogenic or a protective role in the development of RA. Oral intake of probiotics/prebiotics can therefore represent a therapeutic approach for RA treatment. However, the relevant scientific work has only just begun, and the available data in this field remain limited. Fortunately, utilization of new sequencing technologies allows expanded research on the association of intestinal bacterial flora and human diseases to be attempted. In this review, we summarize the role of gut microbiota in RA progression and address how specific bacterial strains regulate the immune response in disease process. Probiotics/prebiotics in the treatment of RA is also discussed.

Indexed as

Administration, OralArthritis, RheumatoidEvidence-Based MedicineGastrointestinal MicrobiomeHumansProbioticsTreatment OutcomeAutoimmune disorderBiomarkersGut microbiota dysbiosis​Probiotic therapyRheumatoid arthritis

Identifiers

PMID27909795
OpenAlexW2558834025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.