ArticleEuropean journal of clinical pharmacology2017
Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma.
Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Continuous Magnesium Sulfate Infusions for Status Asthmaticus in Children: A Systematic Review.Frontiers in pediatrics · 2022Pooled it
- Intravenous Magnesium: Prompt use for Asthma in Children Treated in the Emergency Department (IMPACT-ED), a pilot randomized trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025Trial
- Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations.Journal of clinical pharmacology · 2025Trial
- Effect of magnesium sulfate on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery: a prospective double-blind randomized clinical trial.Korean journal of anesthesiology · 2023Trial
- Association Between Intravenous Magnesium Therapy in the Emergency Department and Subsequent Hospitalization Among Pediatric Patients With Refractory Acute Asthma: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2021Trial
- Magnesium in acute pediatric asthma in the emergency department (MAGICIAN)-A multicentre randomized controlled clinical trial protocol.PloS one · 2026Article
- Effectiveness of Intravenous and Nebulized MgSOChildren (Basel, Switzerland) · 2025Review
- Status asthmaticus and the use of ketamine nebulization and magnesium sulfate: current strategies and outcomes.Annals of medicine and surgery (2012) · 2025Review
- Safety and Effectiveness of Prolonged Magnesium Sulfate (MgSOJournal of pediatric intensive care · 2024Article
- Intravenous Magnesium: Prompt Use for Asthma in Children Treated in the Emergency Department (IMPACT-ED): Protocol for a Multicenter Pilot Randomized Controlled Trial.JMIR research protocols · 2023Article
- A pilot study of the pharmacokinetics of continuous magnesium infusion in critically ill patients.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2022Article
- Efficacy and Safety of Prolonged Magnesium Sulfate Infusions in Children With Refractory Status Asthmaticus.Frontiers in pediatrics · 2022Article
- Stating the obvious: intravenous magnesium sulphate should be the first parenteral bronchodilator in paediatric asthma exacerbations unresponsive to first-line therapy.Breathe (Sheffield, England) · 2021Review
- Trends in Intravenous Magnesium Use and Outcomes for Status Asthmaticus in Children's Hospitals from 2010 to 2017.Journal of hospital medicine · 2020Article
- Efficacy of Magnesium Sulfate Treatment in Children with Acute Asthma.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020Article
- Escalation in Therapy Based on Intravenous Magnesium Sulfate Dosing in Pediatric Patients With Asthma Exacerbations.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Prospective study of serum and ionized magnesium pharmacokinetics in the treatment of children with severe acute asthma.European journal of clinical pharmacology · 2019Article
- Use Profile of Magnesium Sulfate in Anesthesia in Brazil.Frontiers in pharmacology · 2019Article
- The role of magnesium sulfate in the intensive care unit.EXCLI journal · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeIntravenous (IV) magnesium sulfate (MgSO
methodsTo explore the pharmacokinetics (PK) of IV MgSO
resultsThe covariate analysis found that only weight was a significant predictor of magnesium concentrations in children. Estimated model parameters suggested that magnesium exhibits a short serum half-life (2.7 h) in children. The average endogenous magnesium concentration (prior to administration of IV MgSO
conclusionsThese results provide new insight into the disposition of IV MgSO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.