ArticleNeuroImage. Clinical2017
Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Emerging findings of glutamate-glutamine imbalance in the medial prefrontal cortex in attention deficit/hyperactivity disorder: systematic review and meta-analysis of spectroscopy studies.European archives of psychiatry and clinical neuroscience · 2022Pooled it
- Developmental trajectories of glutamate and the variable clinical course of ADHD in youth.Translational psychiatry · 2026Article
- Modulatory Effects of Jujuboside A on Amino Acid Neurotransmitter Profiles in Tic Disorder.Brain and behavior · 2025Article
- Unpacking Tourette Syndrome in Children: Insights into Prevalence and Comorbidities from NSCH Data.Journal of clinical medicine · 2025Article
- The Relationship between Early Exposure to General Anesthesia and Neurobehavioral Deficits.Developmental neuroscience · 2025Review
- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients.Journal of neurodevelopmental disorders · 2023Article
- Tension-Type Headache in Children and Adolescents.Life (Basel, Switzerland) · 2023Review
- Molecular Landscape of Tourette's Disorder.International journal of molecular sciences · 2023Article
- Co-Occurrence of Tic Disorders and Attention-Deficit/Hyperactivity Disorder-Does It Reflect a Common Neurobiological Background?Biomedicines · 2022Review
- A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders.Brain sciences · 2022Article
- Nanomedicine and graphene-based materials: advanced technologies for potential treatments of diseases in the developing nervous system.Pediatric research · 2022Review
- "Glu/GABA-Gln" metabolic loop abnormalities in iminodipropionitrile (IDPN)-induced dyskinetic syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations in Schizophrenia and Autism Spectrum Disorder: Evidence from Human and Rodent Studies.International journal of molecular sciences · 2020Review
- Brain Branched-Chain Amino Acids in Maple Syrup Urine Disease: Implications for Neurological Disorders.International journal of molecular sciences · 2020Review
- Neurochemical Correlates of Executive Function in Children with Attention-Deficit/Hyperactivity Disorder.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2020Article
- Psychopharmacotherapy of Obsessive-Compulsive Symptoms within the Framework of Tourette Syndrome.Current neuropharmacology · 2019Review
- Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models.Translational psychiatry · 2018Article
- GABA and glutamate in children with Tourette syndrome: APsychiatry research. Neuroimaging · 2018Article
- Merging the Pathophysiology and Pharmacotherapy of Tics.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBoth Tourette's disorder (TD) and attention-deficit/hyperactivity disorder (ADHD) have been related to abnormalities in glutamatergic neurochemistry in the fronto-striatal circuitry. TD and ADHD often co-occur and the neural underpinnings of this co-occurrence have been insufficiently investigated in prior studies.
methodWe used proton magnetic resonance spectroscopy (1H-MRS) in children between 8 and 12 years of age (TD
resultsWe did not find any group differences in glutamate concentrations in either the ACC (F
conclusionWe found no evidence for glutamatergic neuropathology in TD or ADHD within the fronto-striatal circuits. However, the correlation of OC-symptoms with ACC glutamate concentrations suggests that altered glutamatergic transmission is involved in OC-symptoms within TD, but this needs further investigation.
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