Evidence map›Paper›PMID 27909552›Full record

ArticleWorld journal of gastrointestinal endoscopy2016

Vonoprazan 20 mg

Kazuya Takahashi, Yuichi Sato, Junji Kohisa, Jun Watanabe, Hiroki Sato, Kenichi Mizuno, Satoru Hashimoto, Shuji Terai

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 8 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 8 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kazuya TakahashiKazuya Takahashi, Yuichi Sato, Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan.
Yuichi SatoKazuya Takahashi, Yuichi Sato, Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan.
Junji KohisaKazuya Takahashi, Yuichi Sato, Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan.
Jun WatanabeKazuya Takahashi, Yuichi Sato, Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan.
Hiroki SatoKazuya Takahashi, Yuichi Sato, Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan.
Kenichi MizunoKazuya Takahashi, Yuichi Sato, Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan.
Satoru HashimotoKazuya Takahashi, Yuichi Sato, Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan.
Shuji TeraiKazuya Takahashi, Yuichi Sato, Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan.
Nagaoka Red Cross Hospital · JPNiigata University · JPSado General Hospital · JPNiigata University Medical and Dental Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection (ESD).

methodsData were obtained from a total of 26 patients. Fourteen patients were randomized to the vonoprazan group and 12 were randomized to the lansoprazole group. Patients were administered either 20 mg vonoprazan or 30 mg lansoprazole per day after ESD. Endoscopic images just after ESD, on day 8, and on day 28 were used for the evaluation of the shrinking rate of ESD ulcers. The shrinking rates and the incidence of delayed bleeding were compared between the 2 groups.

resultsThe shrinking rates of ESD ulcers on day 8 [vonoprazan group: 61.8% (range: 24.0%-91.1%), lansoprazole group: 71.3% (range: 25.2%-88.6%)] and on day 28 [vonoprazan group: 95.3% (range: 76.2%-100%), lansoprazole group: 97.2% (range: 81.1%-99.8%)] were not statistically different between the 2 groups. On day 28, most of the ulcers in both groups healed to more than 90%, whereas 3 of 14 (21.4%) in the vonoprazan group and 1 of 12 (8.3%) in the lansoprazole group had delayed ulcer healing, which was not statistically different (

conclusionOur study indicates that vonoprazan is potent for the management of ESD ulcers although lansoprazole is also sufficient and cost-effective.

Indexed as

Endoscopic submucosal dissectionGastric cancerLansoprazolePotassium-competitive acid blockerProton pump inhibitorVonoprazan

Identifiers

PMID27909552
PMCPMC5114461
OpenAlexW2555206525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.