Evidence map›Paper›PMID 27909437›Full record

ArticleFrontiers in immunology2016

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study.

Anders J Svendsen, Kristina Gervin, Robert Lyle, Lene Christiansen, Kirsten Kyvik, Peter Junker, Christian Nielsen, Gunnar Houen, Qihua Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 47 citations in OpenAlex.

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  8. Article
  9. Role of IFN-α in Rheumatoid Arthritis.Current rheumatology reports · 2024
    Review
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  12. Article
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  19. Article
  20. Hypomethylation of PRDM1 is associated with recurrent pregnancy loss.Journal of cellular and molecular medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Anders J SvendsenThe Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark , Odense , Denmark.
Kristina GervinDepartment of Medical Genetics, Oslo University Hospital, University of Oslo , Oslo , Norway.
Robert LyleDepartment of Medical Genetics, Oslo University Hospital, University of Oslo , Oslo , Norway.
Lene ChristiansenThe Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark , Odense , Denmark.
Kirsten KyvikDenmark and Odense Patient data Explorative Network (OPEN), Institute of Clinical Research, Odense University Hospital, University of Southern Denmark , Odense , Denmark.
Peter JunkerDepartment of Rheumatology, Odense University Hospital, University of Southern Denmark , Odense , Denmark.
Christian NielsenDepartment of Clinical Immunology, Odense University Hospital , Odense , Denmark.
Gunnar HouenDepartment of Clinical Biochemistry and Immunology, Statens Serum Institute , Copenhagen , Denmark.
Qihua TanThe Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
University of Southern Denmark · DKOdense University Hospital · DKOslo University Hospital · NOStatens Serum Institut · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn an explorative epigenome-wide association study (EWAS) to search for gene independent, differentially methylated DNA positions and regions (DMRs) associated with rheumatoid arthritis (RA) by studying monozygotic (MZ) twin pairs discordant for RA.

methodsGenomic DNA was isolated from whole blood samples from 28 MZ twin pairs discordant for RA. DNA methylation was measured using the HumanMethylation450 BeadChips. Smoking, anti-cyclic citrullinated peptide antibodies, and immunosuppressive treatment were included as covariates. Pathway analysis was performed using GREAT.

resultsSmoking was significantly associated with hypomethylation of a DMR overlapping the promoter region of the

conclusionWe identified several differentially methylated regions associated with RA, which may represent environmental effects or consequences of the disease and plausible biological pathways pertinent to the pathogenesis of RA.

Indexed as

DNA methylationepigenome-wide association studymonozygotic twinspathway analysisrheumatoid arthritis

Identifiers

PMID27909437
PMCPMC5112246
OpenAlexW2551599954

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.